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400015 Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem

The Caspase-1 Inhibitor IV, also referenced under CAS 154674-81-4, controls the biological activity of Caspase-1. This small molecule/inhibitor is primarily used for Cancer applications.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: ICE Inhibitor IV, Ac-YVAD-AOM

Primary Target: caspase-1
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Aperçu

Replacement Information

Tableau de caractéristiques principal

CAS #Empirical Formula
154674-81-4C₃₃H₄₂N₄O₁₀

Prix & Disponibilité

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400015-1MG
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      Description
      OverviewA highly selective, competitive, cell-permeable, and irreversible inhibitor of caspase-1, caspase-4, and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
      Catalogue Number400015
      Brand Family Calbiochem®
      SynonymsICE Inhibitor IV, Ac-YVAD-AOM
      References
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.
      Product Information
      CAS number154674-81-4
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₃₃H₄₂N₄O₁₀
      Chemical formulaC₃₃H₄₂N₄O₁₀
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary Targetcaspase-1
      Purity≥96% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      400015-1MG 07790788049935

      Documentation

      Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Caspase-1 Inhibitor IV - CAS 154674-81-4 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      400015

      Références bibliographiques

      Aperçu de la référence bibliographique
      Garcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision01-April-2011 RFH
      SynonymsICE Inhibitor IV, Ac-YVAD-AOM
      DescriptionHighly selective, competitive and irreversible inhibitor of caspase-1 and caspase-5. Inactivates the enzyme with a rate limited by diffusion and is relatively inert toward other bionucleophiles, such as glutathione, making it an excellent candidate for in vivo studies of enzyme inhibition.
      FormWhite solid
      CAS number154674-81-4
      Chemical formulaC₃₃H₄₂N₄O₁₀
      Peptide SequenceAc-Tyr-Val-Ala-Asp-AOM (AOM = 2,6-dimethylbenzoyloxymethyl ketone)
      Structure formulaStructure formula
      Purity≥96% by HPLC
      SolubilityDMSO (5 mg/ml)
      Storage Protect from moisture
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing recosntitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesGarcia-Calvo, M., et al. 1998. J. Biol. Chem. 273, 32608.
      Hilbi, H., et al. 1998. J. Biol. Chem. 273, 32895.
      Thornberry, N.A., and Lazebnik, Y. 1998. Science 281, 1312.
      Thornberry, N.A., et al. 1994. Biochemistry 33, 3934.

      Produits & Applications associés

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      Catégories

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Apoptosis/Necrosis Inhibitors > Caspase Inhibitors