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504345 BX471 - CAS 217645-70-0 - Calbiochem

BX471 - CAS 217645-70-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: N-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752

Primary Target: CCR1
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      217645-70-0C₂₁H₂₄ClFN₄O₃
      Description
      OverviewAn orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
      Catalogue Number504345
      Brand Family Calbiochem®
      SynonymsN-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
      References
      ReferencesShahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
      Reuss, R., et al. 2010. Mult Scler. 16, 366.
      Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
      Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
      Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.
      Product Information
      CAS number217645-70-0
      FormWhite to beige powder
      Hill FormulaC₂₁H₂₄ClFN₄O₃
      Chemical formulaC₂₁H₂₄ClFN₄O₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetCCR1
      Primary Target K<sub>i</sub>1-5 nM
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      504345 0

      Documentation

      BX471 - CAS 217645-70-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      BX471 - CAS 217645-70-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      504345

      Références bibliographiques

      Aperçu de la référence bibliographique
      Shahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
      Reuss, R., et al. 2010. Mult Scler. 16, 366.
      Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
      Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
      Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-April-2019 JSW
      SynonymsN-[5-chloro-2-[2-[(2R)-4-[(4-fluorophenyl)methyl]-2-methyl-1-piperazinyl]-2-oxoethoxy]phenyl]-urea, ZK-811752
      DescriptionAn orally active, selective antagonist for chemokine receptor 1 (CCR-1) (Ki = 1-5 nM). Has been used in studies related to intracellular calcium mobilization and migration of leukocytes mediated through CCR-1.
      FormWhite to beige powder
      CAS number217645-70-0
      Chemical formulaC₂₁H₂₄ClFN₄O₃
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (≥25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesShahlaei, M., et al. 2011. J. Chemical Information and Modeling. 51, 2717.
      Reuss, R., et al. 2010. Mult Scler. 16, 366.
      Gladue, R., et al. 2010. Curr Top Med Chem 10, 1268.
      Vandemeulebroecke; M., et al. 2009. British J. of Clinical Pharmacol. 68, 435.
      Richard Horuk, R. 2005. Mini-Reviews in Medicinal Chemistry. 5, 791.