Millipore Sigma Vibrant Logo

203715 BQ-610 - Calbiochem

A highly selective ETA receptor antagonist (IC₅₀ = 20 nM) that attenuates ET-induced reduction in cardiac output.

BQ-610 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: ETA receptor antagonist
View Products on Sigmaaldrich.com
203715
  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Empirical Formula
      C₃₆H₄₇N₇O₆
      Description
      Overview

      This product has been discontinued.



      A highly selective ETA receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Also inhibits ET-1- and ET-3-induced activation of adenylate cyclase (IC50 = 28.2 nM). BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in porcine aortic smooth muscle membrane assay.
      Catalogue Number203715
      Brand Family Calbiochem®
      References
      ReferencesBeyer, M.E., et al. 1999. Hypertension 33, 145.
      Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
      Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
      Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
      Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.
      Product Information
      ATP CompetitiveN
      FormWhite lyophilized powder
      FormulationSupplied as an ammonium salt.
      Hill FormulaC₃₆H₄₇N₇O₆
      Chemical formulaC₃₆H₄₇N₇O₆
      Hygroscopic Hygroscopic
      ReversibleN
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetETA receptor antagonist
      Primary Target IC<sub>50</sub>20 nM as ETA receptor antagonist that attenuates ET-induced reduction in cardiac output
      Purity≥90% by HPLC
      Physicochemical Information
      Cell permeableN
      Peptide SequenceHomopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      203715 0

      Documentation

      BQ-610 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      BQ-610 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      203715

      Références bibliographiques

      Aperçu de la référence bibliographique
      Beyer, M.E., et al. 1999. Hypertension 33, 145.
      Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
      Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
      Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
      Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-April-2010 JSW
      DescriptionA highly selective endothelin A (ETA) receptor antagonist (IC50 = 20 nM) that attenuates ET-induced reduction in cardiac output. Inhibits ET-1 induced mitogenesis in airway smooth muscle cells in a concentration-dependent manner (IC50 = 20 nM). Also inhibits ET-1 and ET-3 induced activation of adenylate cyclase (IC50 = 28.2 nM). Has been shown to prevent endothelin-induced vasoconstriction. BQ-610 is 30-fold more potent than BQ-123 (Cat. No. 05-23-3831) in a porcine aortic smooth muscle assay.
      FormWhite lyophilized powder
      FormulationSupplied as an ammonium salt.
      Chemical formulaC₃₆H₄₇N₇O₆
      Peptide SequenceHomopiperidinyl-CO-Leu-D-Trp(CHO)-D-Trp-ONH4
      Purity≥90% by HPLC
      SolubilityH₂O (1 mg/ml)
      Storage -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesBeyer, M.E., et al. 1999. Hypertension 33, 145.
      Carratu, P., et al. 1997. Am. J. Physiol. 272, L1021.
      Illing, B., et al. 1996. J. Cardiovasc. Pharmacol. 27, 487.
      Han, H., et al. 1995. J. Mol. Cell. Cardiol. 27, 761.
      Ishikawa, K., et al. 1992. in Peptides, Schneider and Eberle, eds. (ESCOM), p. 685.