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178276 Apicidin, Fusarium sp. - Calbiochem

A potent, cell-permeable inhibitor of histone deacetylase (IC₅₀= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties.

Apicidin, Fusarium sp. - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: cyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI

Primary Target: Histone deacetylase
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178276
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Aperçu

Replacement Information

Tableau de caractéristiques principal

Empirical Formula
C₃₄H₄₉N₅O₆

Prix & Disponibilité

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178276-1MG
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      		 Bidon alu 1 mg
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      178276-5MG
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      Disponibilité limitée Disponibilité limitée
      En stock 
      Interrompu(e)
      Disponible en quantités limitées
      Disponibilité à confirmer
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          Pour le restant : Nous vous tiendrons informé
          Nous vous tiendrons informé
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          Contact Customer Service

          		 Bidon alu 5 mg
          Prix en cours de récupération
          Le prix n'a pas pu être récupéré
          La quantité minimale doit être un multiple de
          Maximum Quantity is
          À la validation de la commande Plus d'informations
          Vous avez sauvegardé ()
           
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          Description
          OverviewA potent, cell-permeable inhibitor of histone deacetylase (IC50= 700 pM for parasitic histone deactetylase) that also exibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50= 50-100 nM) and induces the transcriptional activation of p21 (WAF1). Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2.
          Catalogue Number178276
          Brand Family Calbiochem®
          Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
          References
          ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
          Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
          Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
          Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
          Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.
          Product Information
          ATP CompetitiveN
          FormWhite solid
          Hill FormulaC₃₄H₄₉N₅O₆
          Chemical formulaC₃₄H₄₉N₅O₆
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetHistone deacetylase
          Primary Target IC<sub>50</sub>700 pM for parasitic histone deactetylase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          R PhraseR: 26/27/28

          Very toxic by inhalation, in contact with skin and if swallowed.
          S PhraseS: 22-26-36/37/39-45

          Do not breathe dust.
          In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
          Wear suitable protective clothing, gloves and eye/face protection.
          In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Ambient Temperature Only
          Toxicity Highly Toxic
          Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
          Storage -20°C
          Protect from Light Protect from light
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Référence GTIN
          178276-1MG 04055977222401
          178276-5MG 04055977222418

          Documentation

          Required Licenses

          Title
          PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

          Apicidin, Fusarium sp. - Calbiochem FDS

          Titre

          Fiche de données de sécurité des matériaux (FDS) 

          Apicidin, Fusarium sp. - Calbiochem Certificats d'analyse

          TitreNuméro de lot
          178276

          Références bibliographiques

          Aperçu de la référence bibliographique
          Colletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
          Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
          Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
          Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
          Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.

          Informations techniques

          Titre
          White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
          Fiche technique

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision06-February-2019 JSW
          Synonymscyclo-[L-(2-Amino-8-oxodecanoyl)-L-(N-methoxytryptophan)-L-isoleucyl-D-pipecolinyl], HDAC Inhibitor XI
          DescriptionA potent, cell-permeable inhibitor of histone deacetylase (IC50 = 700 pM for parasitic histone deactetylase) that also exhibits antiprotozoal and potential anti-malarial properties. Inhibits HeLa cell proliferation (IC50 = 50-100 nM) and induces the transcriptional activation of p21 (WAF1) in a reversible manner. Also prevents H-ras-induced invasive phenotype of MCF10A cells possibly by down-regulating MMP-2 in a reversible manner.
          FormWhite solid
          Intert gas (Yes/No) Packaged under inert gas
          Chemical formulaC₃₄H₄₉N₅O₆
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (50 mg/ml) or Ethanol
          Storage Protect from light
          -20°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
          Toxicity Highly Toxic
          ReferencesColletti, S.L., et al. 2001. Bioorg. Med. Chem. Lett. 11, 107.
          Kim, J.S., et al. 2001. Biochem. Biophys. Res. Commun. 281, 866.
          Andrews, K.T., et al. 2000. Int. J. Parasitol. 30, 761.
          Kim, M.S., et al. 2000. Cancer Lett. 157, 23.
          Darkin-Rattray, S.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 13143.