Millipore Sigma Vibrant Logo

07-398 Anti-phospho-NR2B (Ser1303) Antibody

View Products on Sigmaaldrich.com
07-398
200 µg  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
Demander le prix
Disponibilité limitée
Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      Offres spéciales

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Offres spéciales

      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, RWBRbPurifiedPolyclonal Antibody
      Description
      Catalogue Number07-398
      Replaces04-1148
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionAnti-phospho-NR2B (Ser1303) Antibody
      References
      Product Information
      FormatPurified
      HS Code3002 15 90
      Control
      • Brain tissue
      PresentationProtein A Purified immunoglobulin in 30% glycerol, 0.07M Tris-glycine, pH 7.4, 0.105 M NaCl, 0.035% sodium azide as a preservative.
      Quality LevelMQ100
      Applications
      ApplicationAnti-phospho-NR2B (Ser1303) Antibody detects level of phospho-NR2B (Ser1303) & has been published & validated for use in WB.
      Key Applications
      • Western Blotting
      Biological Information
      ImmunogenPeptide corresponding to amino acids 1297-1309 of human phospho-NR2B
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes phospho-NR2B.
      IsotypeIgG
      Species Reactivity
      • Human
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryN-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
      Gene Symbol
      • GRIN2B
      • NR2B
      • MGC142180
      • Glutamate
      • NMDAR2B
      • MGC142178
      • hNR3
      • NR3
      Modifications
      • Phosphorylation
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
      SIZE: 1484 amino acids; 166367 Da
      SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
      SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Molecular Weight~180 kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assuranceroutinely evaluated by immunoblot in a rat brain microsomal protein preparation
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size200 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      07-398 04053252468506

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-phospho-NR2B (Ser1303) Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-phospho-NR2B (Ser1303) Antibody Certificats d'analyse

      TitreNuméro de lot
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) - 2117736 2117736
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) - 2387514 2387514
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) - 2462855 2462855
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) 3086104
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) 2941486
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) 2882015
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) - 2183670 2183670
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) - 2279526 2279526
      Anti-phospho-NR2B (Ser1303) (rabbit polyclonal IgG) - DAM1834034 DAM1834034
      Anti-phospho-NR2B (Ser1303) - 24315 24315

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      A polyamine-deficient diet prevents oxaliplatin-induced acute cold and mechanical hypersensitivity in rats.
      Ferrier, J; Bayet-Robert, M; Pereira, B; Daulhac, L; Eschalier, A; Pezet, D; Moulinoux, JP; Balayssac, D
      PloS one  8  e77828  2013

      Afficher le résumé
      24204988 24204988
      Age-dependent regulation of synaptic connections by dopamine D2 receptors.
      Jia, JM; Zhao, J; Hu, Z; Lindberg, D; Li, Z
      Nature neuroscience  16  1627-36  2013

      Afficher le résumé
      24121738 24121738
      Substrate-selective and calcium-independent activation of CaMKII by α-actinin.
      Jalan-Sakrikar, N; Bartlett, RK; Baucum, AJ; Colbran, RJ
      The Journal of biological chemistry  287  15275-83  2011

      Afficher le résumé
      22427672 22427672
      The N-methyl-D-aspartate-evoked cytoplasmic calcium increase in adult rat dorsal root ganglion neuronal somata was potentiated by substance P pretreatment in a protein kinase C-dependent manner.
      C Castillo,M Norcini,J Baquero-Buitrago,D Levacic,R Medina,J V Montoya-Gacharna,T J J Blanck,M Dubois,E Recio-Pinto
      Neuroscience  177  2010

      Afficher le résumé
      21215796 21215796
      Roles of diverse glutamate receptors in brain functions elucidated by subunit-specific and region-specific gene targeting.
      Mori, Hisashi and Mishina, Masayoshi
      Life Sci., 74: 329-36 (2003)  2003

      Afficher le résumé
      14607261 14607261
      Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease.
      Li, Lijun, et al.
      Neurobiol. Aging, 24: 1113-21 (2003)  2003

      Afficher le résumé
      14643383 14643383
      Mechanism and regulation of calcium/calmodulin-dependent protein kinase II targeting to the NR2B subunit of the N-methyl-D-aspartate receptor.
      Strack, S, et al.
      J. Biol. Chem., 275: 23798-806 (2000)  1999

      Afficher le résumé
      10764765 10764765
      Characterization of NMDA receptor subunit-specific antibodies: distribution of NR2A and NR2B receptor subunits in rat brain and ontogenic profile in the cerebellum.
      Wang, Y H, et al.
      J. Neurochem., 65: 176-83 (1995)  1994

      Afficher le résumé
      7790859 7790859
      Changing subunit composition of heteromeric NMDA receptors during development of rat cortex.
      Sheng, M, et al.
      Nature, 368: 144-7 (1994)  1993

      Afficher le résumé
      8139656 8139656

      Brochure

      Titre
      Pathways and Biomarkers of Glutamatergic Synapse Flyer

      Produits & Applications associés

      Related Products

      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies