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MAB4023 Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2

Detect c-erbB-3 using this Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2 validated for use in ELISA, IH, IP & WB.

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Research Category: Signaling Research Sub-Category: Growth Factors & Receptors Gene Symbol: ERBB3, c-erbB-3, LCCS2, c-erbB3, p85-sErbB3, p45-sErbB3, ErbB-3, erbB3-S, erbB-3, MGC88033, HER3, p180-ErbB3, MDA-BF-1, EC 2.7.10.1 UniProt Number: P21860
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MAB4023
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, IHC, IP, WBMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB4023
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2
      Alternate Names
      • HER-3
      Product Information
      FormatPurified
      PresentationLiquid in PBS, containing azide as a preservative.
      Quality LevelMQ100
      Applications
      ApplicationDetect c-erbB-3 using this Anti-c-erbB-3 Antibody, cytoplasmic domain, clone RTJ2 validated for use in ELISA, IH, IP & WB.
      Key Applications
      • ELISA
      • Immunohistochemistry
      • Immunoprecipitation
      • Western Blotting
      Application NotesWestern blot

      ELISA

      Immunoprecipitation

      Immunohistochemistry

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to a site on the cytoplasmic domain of the human c-erbB-3 oncoprotein
      Epitopecytoplasmic domain
      CloneRTJ2
      HostMouse
      SpecificityReactive with human c-erB-3. In normal tissues, c-erB-3 is found in non-dividing differentiated epithelial cells, neurons, and hepatocytes. In abnormal tissues, c-erB-3 is found in 80% of GI tract tumors and 20% of breast cancers.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized.
      Gene Symbol
      • ERBB3
      • c-erbB-3
      • LCCS2
      • c-erbB3
      • p85-sErbB3
      • p45-sErbB3
      • ErbB-3
      • erbB3-S
      • erbB-3
      • MGC88033
      • HER3
      • p180-ErbB3
      • MDA-BF-1
      • EC 2.7.10.1
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P21860 # Binds and is activated by neuregulins and NTAK.
      SIZE: 1342 amino acids; 148098 Da
      SUBUNIT: Heterodimer with each of the other ERBB receptors (Potential). Interacts with CSPG5 and PA2G4.
      SUBCELLULAR LOCATION: Isoform 1: Cell membrane; Single-pass type I membrane protein. & Isoform 2: Secreted.
      TISSUE SPECIFICITY: Epithelial tissues and brain.
      DOMAIN: SwissProt: P21860 The cytoplasmic part of the receptor may interact with the SH2 or SH3 domains of many signal-transducing proteins.
      PTM: Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (By similarity).
      DISEASE: SwissProt: P21860 # Overexpressed in a subset of human mammary tumors. & Defects in ERBB3 are the cause of lethal congenital contracture syndrome type 2 (LCCS2) [MIM:607598]; also called Israeli Bedouin multiple contracture syndrome type A. LCCS2 is an autosomal recessive neurogenic form of a neonatally lethal arthrogryposis that is associated with atrophy of the anterior horn of the spinal cord. The LCCS2 syndrome is characterized by multiple joint contractures, anterior horn atrophy in the spinal cord, and a unique feature of a markedly distended urinary bladder. The phenotype suggests a spinal cord neuropathic etiology.
      SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. & Contains 1 protein kinase domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain refrigerated at 2-8°C in undiluted aliquots for up to 12 months.
      Packaging Information
      Material Size100 µg
      Global Trade Item Number
      Référence GTIN
      MAB4023 04053252610837