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MAB5782 Anti-NMDAR2B Antibody, NT

Detect NMDAR2B using this Anti-NMDAR2B Antibody, N-terminal validated for use in WB.

Anti-NMDAR2B Antibody, NT : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors Gene Symbol: GRIN2B, MGC142180, Glutamate, NMDAR2B, NR3, NR2B, MGC142178, hNR3 UniProt Number: Q13224
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MAB5782
100 µL  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, M, R, Rb, FWBMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB5782
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NMDAR2B Antibody, NT
      References
      Product Information
      FormatAscites
      PresentationLiquid ascites fluid
      Quality LevelMQ100
      Applications
      ApplicationDetect NMDAR2B using this Anti-NMDAR2B Antibody, N-terminal validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:100-1:1,000 on rat brain lysate.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant protein from rat NMDAR2B.
      Clone1A8.9B3
      HostMouse
      SpecificityNMDAR2B, N-terminal. By Western blot the antibody reacts with bands at ~170 kDa on rat brain lysate. Additional bands at ~116, 50 and 32 kDa may be seen depending on sample and antibody concentration used.
      IsotypeIgG1
      Species Reactivity
      • Human
      • Mouse
      • Rat
      • Rabbit
      • Fish
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryN-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
      Gene Symbol
      • GRIN2B
      • MGC142180
      • Glutamate
      • NMDAR2B
      • NR3
      • NR2B
      • MGC142178
      • hNR3
      Purification MethodAscites
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
      SIZE: 1484 amino acids; 166367 Da
      SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
      SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MAB5782 04053252724466

      Documentation

      Anti-NMDAR2B Antibody, NT FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-NMDAR2B Antibody, NT Certificats d'analyse

      TitreNuméro de lot
      MOUSE ANTI-NMDAR2B - 2211962 2211962
      MOUSE ANTI-NMDAR2B - 3207606 3207606
      MOUSE ANTI-NMDAR2B - 3583854 3583854
      MOUSE ANTI-NMDAR2B - 3671745 3671745
      MOUSE ANTI-NMDAR2B - 3715665 3715665
      MOUSE ANTI-NMDAR2B - 3836460 3836460
      MOUSE ANTI-NMDAR2B - 3979339 3979339
      MOUSE ANTI-NMDAR2B - 4150383 4150383
      MOUSE ANTI-NMDAR2B MONOCLONAL ANTIBODY 3778013
      MOUSE ANTI-NMDAR2B MONOCLONAL ANTIBODY 3069870
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      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Regional, developmental and interspecies expression of the four NMDAR2 subunits, examined using monoclonal antibodies
      Laurie, D J, et al
      Brain Res Mol Brain Res, 51:23-32 (1997)  1997

      		9427503 9427503

      Brochure

      Titre
      Pathways and Biomarkers of Glutamatergic Synapse Flyer

      Fiche technique

      Titre
      MOUSE ANTI-NMDAR2B

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      Alternative Packsize

      Référence Description  
      MAB5782-KC Anti-NMDAR2B, NT, clone 1A8.9B3 (1mL) KC Prix & Disponibilité

      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies