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AB9209 Anti-Metabotropic Glutamate Receptor 2 Antibody

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AB9209
50 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HICC, IH(P), WBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB9209
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Metabotropic Glutamate Receptor 2 Antibody
      Alternate Names
      • mGluR2
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS, pH 7.7 with 0.01% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Metabotropic Glutamate Receptor 2 Antibody detects level of Metabotropic Glutamate Receptor 2 & has been published & validated for use in IC, IH(P) & WB.
      Key Applications
      • Immunocytochemistry
      • Immunohistochemistry (Paraffin)
      • Western Blotting
      Application NotesWestern blot

      Immunohistochemistry on formalin fixed paraffin embedded tissue sections.

      Immunocytochemistry on acetone fixed cells.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from the N-terminal extracellular domain of human Metabotropic Glutamate Receptor 2. The immunogen has 100% conservation with rat.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityRecognizes Metabotropic Glutamate Receptor 2 [mGluR2].
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryL-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities.
      Gene Symbol
      • GRM2
      • mGlu2
      • GPRC1B
      • MGLUR2
      • mGluR2
      • GLUR2
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q14416 # Receptor for glutamate. The activity of this receptor is mediated by a G-protein that inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization.
      SIZE: 872 amino acids; 95568 Da
      SUBUNIT: Interacts with GRASP (By similarity).
      SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Widely expressed in different regions of the adult brain as well as in fetal brain.
      SIMILARITY: SwissProt: Q14416 ## Belongs to the G-protein coupled receptor 3 family.
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -70°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size50 µg
      Global Trade Item Number
      Référence GTIN
      AB9209 04053252338632