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MABC1144 Anti-LMO-2 (Rhombotin-2) Antibody, clone 1A9-3B11

Detect LMO2 using this mouse monoclonal Anti-LMO-2 (Rhombotin-2) Antibody, clone 1A9-3B11, Cat. No. MABC1144, validated for use in Immunohistochemistry (Paraffin).

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Research Category: Apoptosis & Cancer Gene Symbol: LMO2, RBTN2, RBTNL1, RHOM2, TTG2 UniProt Number: P25791
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MABC1144
100 μg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC1144
      DescriptionAnti-LMO-2 (Rhombotin-2) Antibody, clone 1A9-3B11
      Alternate Names
      • Rhombotin-2
      • Cysteine-rich protein TTG-2
      • LIM domain only protein 2
      • LMO-2
      • T-cell translocation protein 2
      Background InformationRhombotin-2 (UniProt P25791; also known as Cysteine-rich protein TTG-2, LIM domain only protein 2, LMO-2, T-cell translocation protein 2) is encoded by the LMO2 (also known as RBTN2, RBTNL1, RHOM2, TTG2) gene (Gene ID 4005) in human. Rhombotin-2 is 158 amino acids, small cysteine-rich protein with multiple functions. A large portion of its structure is occupied by tandemly repeated cysteine-rich zinc-finger binding motifs, the LIM domains. However, it does not have any identifiable DNA-binding motifs. It is found predominantly in the nucleus or in the cytoplasm depending upon both the tissue and the cell type. For example, in kidney it is predominantly localized in the cytoplasm, but in hematopoietic cells it has nuclear localization. LMO2 is reported to be a proto-oncogene only in the context of T lymphocytes and plays a role in T-cell leukemogenesis. It also has distinct functions in erythropoiesis. It acts with TAL1/SCL to regulate red blood cell development and interacts with LDB1 to maintain erythroid precursors in an immature state. It is reported to interact with retinoblastoma-binding protein 2 (RBP2) and human Bex2 (brain expressed X-linked), both of which are shown to enhance its transcriptional activity. A chromosomal aberration involving LMO2 has been linked to T-cell acute lymphoblastic leukemia (T-ALL).
      Ref.: Mao S., et al. (1997) Oncogene 14, 1531-1539.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect LMO2 using this mouse monoclonal Anti-LMO-2 (Rhombotin-2) Antibody, clone 1A9-3B11, Cat. No. MABC1144, validated for use in Immunohistochemistry (Paraffin).
      Key Applications
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:1,000 dilution from a representative lot detected LMO-2 (Rhombotin-2) in human lymphoma and cerebellum tissue sections.

      Clone 1A9-3B11 exhibits similar property as clone 1A9-1 subcloned from the same parental hybridoma culture (Natkunam, Y., et al. (2007). Blood. 109(4):1636-1642). Please refer to Natkunam, Y., et al. (2007) regarding Immunohistochemistry and Western Blotting applications using the related subclone 1A9-1.
      Biological Information
      ImmunogenGST-tagged recombinant human LMO-2 (Rhombotin-2).
      Clone1A9-3B11
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • LMO2
      • RBTN2
      • RBTNL1
      • RHOM2
      • TTG2
      Purification MethodProtein G purified.
      UniProt Number
      Molecular Weight18.36/25.04 kDa (human isoform 1/3) calculated. ~24 kDa reported (Natkunam, Y., et al. (2007). Blood. 109(4):1636-1642).
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human kidney tissue sections.

      Immunohistochemistry Analysis: A 1:1,000 dilution of this antibody detected LMO-2 (Rhombotin-2) in human kidney tissue section.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABC1144 04054839092008