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MABF846 Anti-LAG3 Antibody, clone C9B7W (Azide Free)

MABF846
100 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MFC, ACTRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABF846
      DescriptionAnti-LAG3 Antibody, clone C9B7W (Azide Free)
      Alternate Names
      • LAG3
      • Lymphocyte activation gene 3 protein
      • LAG-3
      • CD223
      Background InformationLymphocyte-activation gene 3 (LAG3), also known as cluster of differentiation 223 (CD223), is an immunoglobulin superfamily (IgSF) type I membrane protein encoded by the LAG3 gene in human. LAG3 is expressed in human activated T and NK cells and involved lymphocyte activation by functioning as a ligand for major histocompatibility complex (MHC) class II molecules.
      References
      Product Information
      FormatPurified
      PresentationPurified rat monoclonal IgG1 in buffer containing PBS without preservatives.
      Quality LevelMQ300
      Applications
      ApplicationAnti-LAG3 Antibody, clone C9B7W (Azide Free) is an antibody against LAG3 for use in Flow Cytometry, Activity Assay.
      Key Applications
      • Flow Cytometry
      • Activity Assay
      Application NotesFlow Cytometry Analysis: A representative lot detected LAG3 in TILs from B16 and MC38 mice (Woo, S., et al. (2011). Cancer Research. 72(4):917-927).
      Flow Cytometry Analysis: A representative lot detected LAG3 in activated T cells from CD223-/- and CD223 +/+ mice (Workman, C.J., et al. (2002). Eur. J. Immunol. 32:2255-2263).
      Flow Cytometry Analysis: A representative lot detected LAG3 in expression of LAG3 on splenocytes stimulated with SEB (Workman, C.J., et al. (2003). Eur. J. Immunol. 33:970-979).
      Flow Cytometry Analysis: A representative lot detected LAG3 in block in-vitro Treg activity (Huang, C., et al. (2004). Immunity. 21:503-513).
      Flow Cytometry Analysis: A representative lot detected LAG3 in LAG-3–/–CD8+Thy1.1+clone 4 CD8+ cells (Grosso, J.F., et al. (2004). J. Clin. Invest. 117(11):3383-3392).
      Activity Assay Analysis: A representative lot detected LAG3 in Inhibits tumor growth (Woo, S., et al. (2011). Cancer Research. 72(4):917-927).
      Activity Assay Analysis: A representative lot detected LAG3 in block in-vitro Treg activity (Huang, C., et al. (2004). Immunity. 21:503-513).
      Activity Assay Analysis: A representative lot detected LAG3 in LAG-3–/–CD8+Thy1.1+clone 4 CD8+ cells (Grosso, J.F., et al. (2004). J. Clin. Invest. 117(11):3383-3392).
      Biological Information
      ImmunogenRecombinant protein corresponding to within the extracellular D2 domain of mouse LAG3.
      EpitopeWithin the extracellular D2 domain
      CloneC9B7w
      ConcentrationPlease refer to lot specific datasheet.
      HostRat
      IsotypeIgG1
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • Lag3
      Purification MethodProtein G Purified
      UniProt Number
      Molecular Weight56 kDa calculated
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Flow Cytometry in Staph enterotoxin B treated mouse splenocyte.

      Flow Cytometry Analysis: 1.0 µg of this antibody detected LAG3 in Staph enterotoxin B treated mouse splenocyte.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at -20°C from date of receipt.
      Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABF846 04055977137187

      Documentation

      Anti-LAG3 Antibody, clone C9B7W (Azide Free) Certificats d'analyse

      TitreNuméro de lot
      Anti-LAG3, clone C9B7W (Azide Free) - 3519819 3519819
      Anti-LAG3, clone C9B7W (Azide Free) -Q2559140 Q2559140

      Références bibliographiques

      Aperçu de la référence bibliographiqueNº PubMed
      Cancer research
      Woo, SR; Turnis, ME; Goldberg, MV; Bankoti, J; Selby, M; Nirschl, CJ; Bettini, ML; Gravano, DM; Vogel, P; Liu, CL; Tangsombatvisit, S; Grosso, JF; Netto, G; Smeltzer, MP; Chaux, A; Utz, PJ; Workman, CJ; Pardoll, DM; Korman, AJ; Drake, CG; Vignali, DA
      Cancer research  72  917-27  2011

      Afficher le résumé
      22186141 22186141
      The Journal of clinical investigation
      Grosso, JF; Kelleher, CC; Harris, TJ; Maris, CH; Hipkiss, EL; De Marzo, A; Anders, R; Netto, G; Getnet, D; Bruno, TC; Goldberg, MV; Pardoll, DM; Drake, CG
      The Journal of clinical investigation  117  3383-92  2007

      Afficher le résumé
      17932562 17932562
      Immunity
      Huang, CT; Workman, CJ; Flies, D; Pan, X; Marson, AL; Zhou, G; Hipkiss, EL; Ravi, S; Kowalski, J; Levitsky, HI; Powell, JD; Pardoll, DM; Drake, CG; Vignali, DA
      Immunity  21  503-13  2004

      Afficher le résumé
      15485628 15485628
      European journal of immunology
      Workman, CJ; Vignali, DA
      European journal of immunology  33  970-9  2003

      Afficher le résumé
      12672063 12672063
      European journal of immunology
      Workman, CJ; Rice, DS; Dugger, KJ; Kurschner, C; Vignali, DA
      European journal of immunology  32  2255-63  2002

      Afficher le résumé
      12209638 12209638

      Brochure

      Titre
      NPI Flyer- Epigenetics and Nuclear Function Feature

      Informations techniques

      Titre
      White Paper: Further considerations of antibody validation and usage.

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies