Millipore Sigma Vibrant Logo

MABC967 Anti-Kallikrein 7/KLK7 Antibody, clone 73-1

Detect KLK7 using this mouse monoclonal Anti-Kallikrein 7/KLK7 Antibody, clone 73-1, Cat. No. MABC967. It was used in ELISA and Immunohistochemistry (Paraffin).

Anti-Kallikrein 7/KLK7 Antibody, clone 73-1 : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Apoptosis & Cancer Gene Symbol: KLK7, PRSS6, SCCE UniProt Number: P49862
View Products on Sigmaaldrich.com
MABC967
100 μg  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, IH(P)MPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMABC967
      DescriptionAnti-Kallikrein 7/KLK7 Antibody, clone 73-1
      Alternate Names
      • KLK7
      • Kallikrein-7
      • hK7
      • Serine protease 6
      • Stratum corneum chymotryptic enzyme
      • hSCCE
      Background InformationKallikrein-7 (UniProt: P49862; also known as hK7, Serine protease 6, Stratum corneum chymotryptic enzyme, hSCCE) is encoded by the KLK7 (also known as PRSS6, SCCE) gene (Gene ID: 5650) in human. KLK7 is a member of the 15-member kallikrein subfamily of serine proteases. Human KLK7 displays 40 60% amino acid homology with other members of the family. Members of this family are involved in diverse physiological functions and serve as biomarkers for cancer. Increased expression of KLK7 is associated with unfavorable prognosis and progression of ovarian cancer. Less differentiated tumors of more advanced stage show higher level KLK7 expression. KLK7 has chymotrypsin-like activity and cleaves proteins with aromatic side chains in the P1 position. Its activity is inhibited by Zn2+ and Cu2+. KLK7 catalyzes the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. It is also reported to play a role in the activation of precursors to inflammatory cytokines.
      References
      Product Information
      FormatPurified
      PresentationPurified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect KLK7 using this mouse monoclonal Anti-Kallikrein 7/KLK7 Antibody, clone 73-1, Cat. No. MABC967. It was used in ELISA and Immunohistochemistry (Paraffin).
      Key Applications
      • ELISA
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry Analysis: A 1:250 dilution from a representative lot detected Kallikrein 7/KLK7 in human kidney tissue and human bone marrow.

      ELISA Analysis: A representative lot detected Kallikrein 7/KLK7 in ELISA applications (Shan, S.J., et. al. (2006). Clin Chem. 52(10):1879-86; Kishi, T., et. al. (2004). Clin Chem. 50(4):709-16).
      Biological Information
      ImmunogenA full length recombinant human pro-Kallikrein 7.
      Clone73-1
      ConcentrationPlease refer to lot specific datasheet.
      HostMouse
      SpecificityClone 73-1 specifically detects kallikrein 7 (KLK7) in human.
      IsotypeIgG1κ
      Species Reactivity
      • Human
      Species Reactivity NoteHuman.
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • KLK7
      • PRSS6
      • SCCE
      UniProt Number
      Molecular Weight27.53 kDa calculated.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human skin tissue.

      Immunohistochemistry Analysis: A 1:250 dilution of this antibody detected Kallikrein 7/KLK7 in human skin tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MABC967 04054839167485