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MAB1152 Anti-Interferon-γ Antibody, clone RMMG-1

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MAB1152
500 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      MELISA, IP, WB, IHC, NEUTRPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB1152
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Interferon-γ Antibody, clone RMMG-1
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in PBS containing 0.1% bovine serum albumin.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Interferon-γ Antibody, clone RMMG-1 is an antibody against Interferon-γ for use in ELISA, IP, WB, IH, NEUT.
      Key Applications
      • ELISA
      • Immunoprecipitation
      • Western Blotting
      • Immunohistochemistry
      • Neutralizing
      Application NotesNeutralizes mouse IFNgamma; binds to mouse IFNgamma with high affinity (KA= 10E9 M-1)

      Western blot (1:500)

      Immunoprecipitation

      Immunohistochemistry

      ELISA

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenMouse Interferon gamma
      CloneRMMG-1
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRat
      SpecificityReacts with mouse Interferon gamma (IFNgamma).
      IsotypeIgG1
      Species Reactivity
      • Mouse
      Antibody TypeMonoclonal Antibody
      Gene Symbol
      • IFNG
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01579 # Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons.
      SIZE: 166 amino acids; 19348 Da
      SUBUNIT: Homodimer.
      SUBCELLULAR LOCATION: Secreted.
      TISSUE SPECIFICITY: Released primarily from activated T lymphocytes.
      PTM: Proteolytic processing produces C-terminal heterogeneity, with proteins ending alternatively at Gly-150, Met-157 or Gly-161.
      DISEASE: SwissProt: P01579 # In Caucasians, genetic variation in IFNG is associated with the risk of aplastic anemia (AA) [MIM:609135]. AA is a rare disease in which the reduction of the circulating blood cells results from damage to the stem cell pool in bone marrow. In most patients, the stem cell lesion is caused by an autoimmune attack. T-lymphocytes, activated by an endogenous or exogenous, and most often unknown antigenic stimulus, secrete cytokines, including IFN-gamma, which would in turn be able to suppress hematopoiesis.
      SIMILARITY: SwissProt: P01579 ## Belongs to the type II (or gamma) interferon family.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain frozen at -20°C or below for retention of full activity, for up to 12 months. When thawing, the contents of the tube should be apportioned in separate tubes so that freezing and thawing is kept to a minimum.
      Packaging Information
      Material Size500 µg
      Global Trade Item Number
      Référence GTIN
      MAB1152 04053252314629