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06-429-I Anti-IGF-IRα subunit Antibody

This Anti-IGF-IRα subunit Antibody is validated for use in Western Blotting, Immunoprecipitation, Immunocytochemistry for the detection of IGF-IRα subunit.

Anti-IGF-IRα subunit Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Signaling Research Sub-Category: Signaling Neuroscience Gene Symbol: IGF1R UniProt Number: P08069
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06-429-I
100 μg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IP, ICCChAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number06-429-I
      DescriptionAnti-IGF-IRα subunit Antibody
      Alternate Names
      • Insulin-like growth factor 1 receptor
      • Insulin-like growth factor I receptor
      • IGF-I receptor
      • CD221
      • Insulin-like growth factor 1 receptor alpha chain
      • Insulin-like growth factor 1 receptor beta chain
      • IGF-IRα subunit
      Background InformationInsulin-like growth factor 1 receptor (EC:2.7.10.1; UniProt P08069; also known as CD221, IGF-I receptor, Insulin-like growth factor I receptor) is encoded by the IGF1R (also known as CD221, IGFIR, IGFR, JTK13) gene (Gene ID 3480) in human. The insulin-like growth factor 1 (IGF-1) receptor has tyrosine kinase that is activated by IGF-1 and IGF-2 binding. IGF-1 receptor is initially produced as a precursor protein with an aignal peptide sequence (aa 1-30). Post-translational cleavages produce one extracellular alpha (aa 31-736) chain and one transmembrane beta chain (aa 741 – 1367) linked together by a disulfide bond. Two sets of alpha-beta dimers then form the functional tetrameric receptor complex via a disulfide linkage between their alpha chain. Upon ligand binding, the alpha chains induce the tyrosine auto-phosphorylation of the beta chains, which in turn triggers cell type-specific downstream signaling cascade of events.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified chicken polyclonal IgY antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-IGF-IRα subunit Antibody is validated for use in Western Blotting, Immunoprecipitation, Immunocytochemistry for the detection of IGF-IRα subunit.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      • Immunocytochemistry
      Application NotesImmunoprecipitation Analysis: 5.0 µg from a representative lot immunoprecipitated human IGF-IRα subunit in 0.5 mg of human IGF-IR-expressing C4 cell lysate.
      Immunocytochemistry Analysis: 2.0 µg/mL from a representative lot detected IGF-IRα subunit in human IGF-IR-expressing C4 cells.
      Biological Information
      ImmunogenKLH-conjugated synthetic peptide [C-KYADGTIDIEEVTENPKT] corresponding to amino acid residues 672-689 of human IGF-IR alpha chain.
      EpitopeThird Fibronectin Type III (FnIII 3) domain
      ConcentrationPlease refer to lot specific datasheet.
      HostChicken
      IsotypeIgY
      Species Reactivity
      • Human
      Species Reactivity NoteHuman. Predicted to react with Rhesus Macaque based on 100% sequence homology.
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • IGF1R
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~110/180 kDa observed
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blotting in human IGF-IR-expressing murine fibroblast LISN C4 cell lysate.

      Western Blotting Analysis: 0.2 µg/mL of this antibody detected IGF-IRα subunit in 10 µg of human IGF-IR-expressing murine fibroblast LISN C4 cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 μg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      06-429-I 04055977182453

      Documentation

      Anti-IGF-IRα subunit Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-IGF-IRα subunit Antibody Certificats d'analyse

      TitreNuméro de lot
      Anti-IGF-IRα subunit - 3268883 3268883
      Anti-IGF-IRα subunit - 4045750 4045750
      Anti-IGF-IRα subunit -Q2589621 Q2589621
      Anti-IGF-IRα subunit -Q2589625 Q2589625

      Brochure

      Titre
      New Products Flyer- Vol 4 Signaling Feature- NEW! Phosphohistidine Antibody

      Informations techniques

      Titre
      Characterization of Estrogen Receptor α Phosphorylation Sites in Breast Cancer Tissue Using the SNAP i.d® 2.0 System
      White Paper: Further considerations of antibody validation and usage.

      Posters

      Titre
      Post-Translational Modifications

      Produits & Applications associés

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      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies