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MAB394-25UG Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2

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MAB394-25UG
25 µg  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RILMSaporinMonoclonal Antibody
      Description
      Catalogue NumberMAB394-25UG
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2
      Product Information
      FormatSaporin
      PresentationSaporin Conjugated. Sterile liquid. Provided in phosphate buffered saline. Contains no preservative.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Dopamine β Hydroxylase-SAP Antibody, clone 4F10.2 is validated for use in 0 for the detection of Dopamine β Hydroxylase.
      Key Applications
      • Immunolesioning
      Application NotesImmunotoxin
      Biological Information
      Clone4F10.2
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityDopamine b-HydroxylaseDBH is a single gene product that exists as a cytosolic enzyme, as a membrane protein and is secreted into the circulation (Lewis & Asnani, 1992). Because of its residence time as a plasma membrane-bound protein, it is able to be used as a targeting agent for neurons. The target neurons include postganglionic sympathetic neurons and all noradrenergic and adrenergic neurons of the central nervous system. As such anti-DBH-SAP can be used for the production of acute peripheral autonomic failure in a model for the human disease. It can also be used for the analysis of the behavioral effects of noradrenergic or adrenergic ablation. When injected intraventricularly, noradrenergic neurons of the locus coeruleus are eliminated (Wiley & Lappi, 1994). The antibody and immunotoxin undergo retrograde transport.

      MAB308 is the unconjugated monoclonal used for MAB394-SAP.
      IsotypeIgG1
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
      Gene Symbol
      • DBH
      • DBM
      • EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase].
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline.
      COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit.
      SIZE: 617 amino acids; 69065 Da
      SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers.
      SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential).
      DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
      SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsThe material should be stored at -80°C for up to six months under sterile conditions. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size25 µg
      Global Trade Item Number
      Référence GTIN
      MAB394-25UG 04053252501647