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AB1537 Anti-Dopamine β Hydroxylase Antibody, CT

This Anti-Dopamine β Hydroxylase Antibody, C-terminus is validated for use in WB, IH for the detection of Dopamine β Hydroxylase.

Anti-Dopamine β Hydroxylase Antibody, CT : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Neuroscience Research Sub-Category: Neurotransmitters & Receptors, Neuronal & Glial Markers Gene Symbol: DBH, DBM, EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase]. UniProt Number: P09172
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AB1537
100 µL  
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      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MkWB, IHCShAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB1537
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Dopamine β Hydroxylase Antibody, CT
      Alternate Names
      • DBH
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in 10 mM HEPES, pH 7.5, 150 mM NaCl, 100 μg/mL BSA and 50% glycerol.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-Dopamine β Hydroxylase Antibody, C-terminus is validated for use in WB, IH for the detection of Dopamine β Hydroxylase.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunoblotting: 1:250-1:1,000 on human, monkey and bovine adrenal medulla.

      Immunohistochemistry: 1:250-1:1,000, staining was evaluated in the locus coeruleus of formaldehyde-fixed, cryopreserved human and monkey brain. Showed strong staining on both human and monkey.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide, CPTSQGRSPAGPTVVSI-amide, from C-terminal region of human (DbetaH).
      EpitopeC-terminus
      HostSheep
      SpecificityDopamine Beta Hydroxylase (DbetaH) C-terminal. By immunoblot the antibody specifically reacts with a single (or double) band(s) of M.W. »70-75,000 in samples of SDS-solubilized, DTT-reduced human adrenal medulla subjected to SDS-PAGE.
      Species Reactivity
      • Human
      • Monkey
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThe protein encoded by this gene is an oxidoreductase belonging to the copper type II, ascorbate-dependent monooxygenase family. It is present in the synaptic vesicles of postganglionic sympathetic neurons and converts dopamine to norepinephrine. It exists in both soluble and membrane-bound forms, depending on the absence or presence, respectively, of a signal peptide.
      Gene Symbol
      • DBH
      • DBM
      • EC 1.14.17.1 [Contains: Soluble dopamine beta-hydroxylase].
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P09172 # Conversion of dopamine to noradrenaline.
      COFACTOR: Binds 1 PQQ per subunit. & Binds 2 copper ions per subunit.
      SIZE: 617 amino acids; 69065 Da
      SUBUNIT: Homotetramer composed of two non-covalently bound disulfide-linked dimers.
      SUBCELLULAR LOCATION: Soluble dopamine beta-hydroxylase: Cytoplasmic vesicle, secretory vesicle lumen. Cytoplasmic vesicle, secretory vesicle, chromaffin granule lumen. & Cytoplasmic vesicle, secretory vesicle membrane; Single-pass type II membrane protein. Cytoplasmic vesicle, secretory vesicle, chromaffin granule membrane; Single- pass type II membrane protein (Potential).
      DISEASE: SwissProt: P09172 # Defects in DBH are the cause of DBH deficiency [MIM:223360]; also called norepinephrine deficiency or noradrenaline deficiency. This disorder is characterized by profound deficits in autonomic and cardiovascular function, but apparently only subtle signs, if any, of central nervous system dysfunction.
      SIMILARITY: SwissProt: P09172 ## Belongs to the copper type II ascorbate-dependent monooxygenase family. & Contains 1 DOMON domain.
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20 to -70°C in undiluted aliquots for up to six months. Avoid repeated freeze-thaw cycles.
      Packaging Information
      Material Size100 µL
      Global Trade Item Number
      Référence GTIN
      AB1537 04053252373886