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ABC462 Anti-DNA polymerase subunit gamma-1 Antibody/POLG

This Anti-DNA polymerase subunit gamma-1 Antibody/POLG is validated for use in Immunohistochemistry and Immunoprecipitation for the detection of DNA polymerase subunit gamma-1/POLG.

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Research Category: Apoptosis & Cancer Research Sub-Category: Apoptosis - Additional Gene Symbol: POLG, MDP1, POLG1, POLGA UniProt Number: P54098
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ABC462
100 µg  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HIHC, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABC462
      ReplacesMABN1088
      DescriptionAnti-DNA polymerase subunit gamma-1 Antibody/POLG
      Alternate Names
      • DNA polymerase subunit gamma-1
      • DNA polymerase subunit gamma-1
      • PolG-alpha
      Background InformationPOLG is a mitochondrial protein that plays a major role in mitochondrial DNA replication and only for mitochondrial DNA. POLG is the catalytic subunit of a multiple protein complex that makes up the holo-enzyme that is the mitochondrial specific DNA polymerase gamma. POLG makes the alpha subunit of the complex. A number of diseases are associated with mutations that affect the function of POLG and the mitochondria including Leigh syndrome, various neurodegeneration diseases such as Parkinson’s and Alzheimer's, as well as various skeletal muscle and ophthalmoplegia disorders and even male infertility. The polymerase that POLG ultimately comprises is Polymerase gamma (Pol γ) and is the only DNA polymerase that is active in mitochondria and that can replicate mtDNA.
      References
      Product Information
      FormatAffinity Purified
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Anti-DNA polymerase subunit gamma-1 Antibody/POLG is validated for use in Immunohistochemistry and Immunoprecipitation for the detection of DNA polymerase subunit gamma-1/POLG.
      Key Applications
      • Immunohistochemistry
      • Immunoprecipitation
      Application NotesImmunohistochemistry Analysis: A 1:50 dilution from a representative lot detected DNA polymerase subunit gamma-1/POLG in human cerebellum, human cerebral cortex, human tonsil and human thalamus tissue.
      Immunoprecipitation Analysis: 10 µg from a representative lot immunoprecipitated DNA polymerase subunit gamma-1/POLG in 0.5 mg of HeLa cell lysate.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human DNA polymerase subunit gamma-1/POLG near the N-terminus.
      EpitopeNear N-terminus
      Concentration1.0 mg/mL
      HostRabbit
      Species Reactivity
      • Human
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • POLG
      • MDP1
      • POLG1
      • POLGA
      Purification MethodAffinity Purfied
      UniProt Number
      Molecular Weight~140 kDa observed. Uncharacterized band(s) may appear in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Immunohistochemistry in human tonsil tissue.

      Immunohistochemistry Analysis: A 1:50 dilution of this antibody detected DNA polymerase subunit gamma-1/POLG in human tonsil tissue.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      ABC462 04053252981821