Millipore Sigma Vibrant Logo

MAB3706 Anti-CD4 Antibody, intracellular, clone 024-10D6.B3

Detect CD4 using this Anti-CD4 Antibody, intracellular, clone 024-10D6.B3 validated for use in ELISA, EMSA, FUNC & IC.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Inflammation & Immunology Research Sub-Category: Immunoglobulins & Immunology Gene Symbol: CD4, CD4mut UniProt Number: P01730
View Products on Sigmaaldrich.com
MAB3706
100 µg  
Prix en cours de récupération
Le prix n'a pas pu être récupéré
La quantité minimale doit être un multiple de
Maximum Quantity is
À la validation de la commande Plus d'informations
Vous avez sauvegardé ()
 
—
Demander le prix
—
Disponibilité limitée Disponibilité limitée
En stock 
Interrompu(e)
Disponible en quantités limitées
Disponibilité à confirmer
    Pour le restant : Nous vous tiendrons informé
      Pour le restant : Nous vous tiendrons informé
      Nous vous tiendrons informé
      Contacter le Service Clients
      Contact Customer Service

      Offres spéciales

       

      Contacter le Service Clients

      Aperçu

      Replacement Information

      Offres spéciales

      100% Performance Guaranteed

      Tableau de caractéristiques principal

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HELISA, EMSA, FUNC, ICCMPurifiedMonoclonal Antibody
      Description
      Catalogue NumberMAB3706
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-CD4 Antibody, intracellular, clone 024-10D6.B3
      References
      Product Information
      FormatPurified
      PresentationPurified immunoglobulin. Liquid in 0.02 M phosphate buffer, 0.25M NaCl, with 0.1% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect CD4 using this Anti-CD4 Antibody, intracellular, clone 024-10D6.B3 validated for use in ELISA, EMSA, FUNC & IC.
      Key Applications
      • ELISA
      • Electrophoretic Mobility Shift Assay
      • Affects Function
      • Immunocytochemistry
      Application NotesImmunocytochemistry

      ELISA

      Stimulation/Inhibition of biological activity

      Electrophoretic mobility shift analysis

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenSynthetic peptide corresponding to amino acids 439-458 of the cytoplasmic tail of human CD4.
      Epitopeintracellular
      Clone024-10D6.B3
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostMouse
      SpecificityRecognizes the cytoplasmic tail of CD4. Many functions have been assigned to this tail, including anti-viral regulation (down/up regulation of CD4), T-cell maturation, activation and differentiation, and Lck signal transduction, among others. This antibody is useful as a control for studies involving targeting of intracellular protein domains of T cells.
      IsotypeIgG1
      Species Reactivity
      • Human
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • CD4
      • CD4mut
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P01730 # Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation. Induces the aggregation of lipid rafts.
      SIZE: 458 amino acids; 51111 Da
      SUBUNIT: Associates with LCK. Binds to HIV-1 gp120 and to P4HB/PDI and upon HIV-1 binding to the cell membrane, is part of P4HB/PDI- CD4-CXCR4-gp120 complex. Interacts with HIV-1 Envelope polyprotein gp160 and protein Vpu.
      SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein. Note=Localizes to lipid rafts. Removed from plasma membrane by HIV-1 Nef protein that increases clathrin-dependent endocytosis of this antigen to target it to lysosomal degradation. Cell surface expression is also down-modulated by HIV-1 Envelope polyprotein gp160 that interacts with, and sequesters CD4 in the endoplasmic reticulum.
      PTM: Palmitoylation and association with LCK contribute to the enrichment of CD4 in lipid rafts.
      SIMILARITY: SwissProt: P01730 ## Contains 3 Ig-like C2-type (immunoglobulin-like) domains. & Contains 1 Ig-like V-type (immunoglobulin-like) domain.
      MISCELLANEOUS: Primary receptor for HIV-1.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at 2-8°C for up to 12 months from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      MAB3706 04053252612534

      Documentation

      Anti-CD4 Antibody, intracellular, clone 024-10D6.B3 FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-CD4 Antibody, intracellular, clone 024-10D6.B3 Certificats d'analyse

      TitreNuméro de lot
      MOUSE ANTI-HUMAN CD4 (INTRACELLULAR EPITOPE) MONOCLONAL ANTIBODY - 2379344 2379344
      MOUSE ANTI-HUMAN CD4 (INTRACELLULAR EPITOPE) - 3492213 3492213
      MOUSE ANTI-HUMAN CD4 (INTRACELLULAR EPITOPE) - 3882001 3882001
      MOUSE ANTI-HUMAN CD4 (INTRACELLULAR EPITOPE) MONOCLONAL ANTIBODY 2935885

      Produits & Applications associés

      Related Products

      Référence Description  
      FCMAB170F Milli-Mark Anti-CD4 -FITC Antibody, clone MT310 Prix & Disponibilité
      MABF1718 Anti-CD4 (human), PE, clone RPA-T4 Antibody Prix & Disponibilité
      MABF1719 Anti-CD4 (human), PE, clone RPA-T4 Antibody Prix & Disponibilité
      MABF1720 Anti-CD4 (human), PE, clone RPA-T4 Antibody Prix & Disponibilité
      MABF1723 Anti-CD4 (human), PerCP, clone SK3 Antibody Prix & Disponibilité
      MABF1724 Anti-CD4 (human), PerCP, clone SK3 Antibody Prix & Disponibilité
      MABF1725 Anti-CD4 (human), PerCP, clone SK3 Antibody Prix & Disponibilité
      MABF1727 Anti-CD4 (human), violetFluor™ 450, clone RPA-T4 Antibody Prix & Disponibilité
      MABF416 Anti-CD4 Antibody (human), APC, clone OKT4 Prix & Disponibilité
      MABF417 Anti-CD4 Antibody (human), PE, clone OKT4 Prix & Disponibilité
      Show more

      Alternative Packsize

      Référence Description  
      MAB3706-KC Anti-CD4, intracellular, clone 024-10D6.B3 Pur (1mg) KC Prix & Disponibilité

      Familles de produits

      CD4 Antibodies

      Millipore’s CD4 Antibodies demonstrate specificity against CD4, a 55 kDa glycoprotein. See below for related products for CD4, based on the expertise of Upstate & Chemicon.
      En savoir plus >>

      Catégories

      Life Science Research > Antibodies and Assays > Primary Antibodies