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07-2189 Anti-CAPZIP Antibody

Anti-CAPZIP detects levels of CAPZIP proteins & has been published & validated for use in WB & IP.

Anti-CAPZIP Antibody : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Research Category: Signaling Research Sub-Category: Cytoskeletal Signaling Gene Symbol: MK2S4, CAPZIP UniProt Number: Q6JBY9
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07-2189
100 µL  
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      Species ReactivityKey ApplicationsHostFormatAntibody Type
      HWB, IPRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue Number07-2189
      DescriptionAnti-CAPZIP Antibody
      Alternate Names
      • RCSD domain containing 1
      • capZ-interacting protein
      • Protein kinase substrate CapZIP
      • protein kinase substrate MK2S4
      • RCSD domain-containing protein 1
      Background InformationCAPZIP (CapZ-interacting protein) is highly expressed in immune cells and muscle and uniquely interacts with CapZ, an F-actin capping protein, in splenocytes. Phosphorylation of CAPZIP is thought to regulate CapZ ability to remodel actin filament assembly. CAPZIP may also contain a CPI (capping protein interaction) motif that seems to restrict capping protein to a low-affinity, filament-binding conformation.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Jurkat cell lysate
      PresentationPurified rabbit polyclonal in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationAnti-CAPZIP detects levels of CAPZIP proteins & has been published & validated for use in WB & IP.
      Key Applications
      • Western Blotting
      • Immunoprecipitation
      Application NotesImmunoprecipitation Analysis: 10 µg from a previous lot immunoprecipitated CAPZIP from Jurkat cell lysate.
      Biological Information
      ImmunogenGST-tagged recombinant protein corresponding to human CAPZIP.
      HostRabbit
      Species Reactivity
      • Human
      Species Reactivity NoteDemonstrated to react with human. Other homologies: Mouse (64% sequence homology). Rat (58% sequence homology).
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Gene Symbol
      • MK2S4
      • CAPZIP
      Purification MethodAffinity Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Stress-induced phosphorylation of CAPZIP may regulate the ability of F-actin-capping protein to remodel actin filament assembly.

      SUBUNIT STRUCTURE: Interacts with CAPZA2 and CAPZB.

      TISSUE SPECIFICITY: Highly expressed in skeletal muscle and more weakly in cardiac muscle. Also expressed in several lymphoid organs, including spleen, thymus, peripheral blood leukocytes, lymph node and bone marrow.

      POST-TRANSLATIONAL MODIFICATION: Dephosphorylation results in its dissociation from CAPZA2.

      SEQUENCE SIMILARITIES: Contains 1 RCSD domain.

      SEQUENCE CAUTION: The sequence CAB70910.1 differs from that shown. Reason: Erroneous initiation.
      Molecular Weight~70 kDa observed. The native form of CAPZIP runs anomalously, with a molecular mass of 70 kDa (much slower than its real molecular mass). The 47 kDa band may be non-specific, a splice variant or a degradation product. (Eyers, C.E., et al. (2005). Biochem J. 389(1):127-135.). An uncharacterized band appears at ~18 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in Jurkat cell lysate.

      Western Blot Analysis: 1:250 dilution of this antibody detected CAPZIP on 10 µg of Jurkat cell lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      07-2189 04053252629457

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Anti-CAPZIP Antibody FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Anti-CAPZIP Antibody Certificats d'analyse

      TitreNuméro de lot
      Anti-CAPZIP - 2385157 2385157
      Anti-CAPZIP - 2445052 2445052
      Anti-CAPZIP - 2517364 2517364
      Anti-CAPZIP - 3594292 3594292
      Anti-CAPZIP - 3821598 3821598
      Anti-CAPZIP - NRG1854603 NRG1854603
      Anti-CAPZIP -2630763 2630763
      Anti-CAPZIP -2676690 2676690
      Anti-CAPZIP Polyclonal Antibody 3033870