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176695 Angeli’s Salt - CAS 13826-64-7 - Calbiochem

A nitroxyl anion (NO⁻) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound.

Angeli’s Salt - CAS 13826-64-7 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Sodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate

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176695
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Tableau de caractéristiques principal

CAS #Empirical Formula
13826-64-7N₂O₃ · 2Na

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176695-10MG
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      Description
      OverviewA nitroxyl anion (NO–) donor that spontaneously dissociates in a pH dependent first order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) in 100 mM phosphate buffer, pH 7.4 is 2.3 minutes at 37°C. Decomposition is nearly instantaneous at pH 5.0.
      Catalogue Number176695
      Brand Family Calbiochem®
      SynonymsSodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate
      References
      ReferencesMiranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
      Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
      Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
      Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
      Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
      Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
      Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.
      Product Information
      CAS number13826-64-7
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaN₂O₃ · 2Na
      Chemical formulaN₂O₃ · 2Na
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetNitroxyl anion (NO-) donor
      Purity≥99%
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      176695-10MG 04055977222951

      Documentation

      Angeli’s Salt - CAS 13826-64-7 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Angeli’s Salt - CAS 13826-64-7 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      176695

      Références bibliographiques

      Aperçu de la référence bibliographique
      Miranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
      Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
      Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
      Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
      Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
      Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
      Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision26-July-2018 JSW
      SynonymsSodium α-Oxyhyponitrite, Disodium Diazen-1-ium-1,2,2-triolate, AS, Sodium Trioxodinitrate
      DescriptionA nitroxyl anion (NO-) donor that spontaneously, in the presence of oxygen and Cu2+ and Fe3+, dissociates in a pH-dependent, first-order process to liberate 0.54 moles of NO per mole of the parent compound. Half-life (t½) of NO release = 2.3 min. (in 100 mM phosphate buffer, pH 7.4 at 37°C). Induces relaxation of norepinephrine-constricted rabbit aorta (EC50 = 590 nM). Angeli's Salt produces nitroxyl anion (NO-) that can be converted to NO in the presence of heme.
      FormCrystalline solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number13826-64-7
      Chemical formulaN₂O₃ · 2Na
      Structure formulaStructure formula
      Purity≥99%
      SolubilityAlkaline solutions (0.01 M NaOH)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in alkaline solution, store at -20°C. This product is stable for 6 months as supplied. Alkaline stock solutions are stable for up to 24 h at -20°C. Unstable in acidic or neutral pH buffers.
      Toxicity Standard Handling
      ReferencesMiranda, K.M., et al. 2001. J. Biol. Chem. 276, 1720.
      Hrinczenko, B.W., et al. 2000. Br. J. Haematol. 110, 412.
      Nelli, S., et al. 2000. Br. J. Pharmacol. 131, 356.
      Ma, X.L., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 14617.
      Keefer, L.K., et al. 1996. Methods Enzymol. 268, 281.
      Fukuto, J.M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 707.
      Maragos, C.M., et al. 1991. J. Med. Chem. 34, 3242.