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126855 Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem

An amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Alendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate

Primary Target: Farnesyl diphosphate synthase
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126855
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Tableau de caractéristiques principal

CAS #Empirical Formula
121268-17-5C₄H₁₂NNaO₇P₂ • 3H₂O

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126855-100MG
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      Description
      OverviewAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts and induces in vitro apoptosis of osteoclasts and macrophages by inhibiting farnesyl diphosphate synthase (IC50 = 460 nM). Efficiently chelates metal ions and functions as a broad-spectrum MMP inhibitor (IC50 ~ 40 - 70 µM). Also displays antimetastatic, anti-invasive and cell-adhesion-promoting properties (IC50 ~ 1 pM, in vitro invasion of prostate cancer cells).
      Catalogue Number126855
      Brand Family Calbiochem®
      SynonymsAlendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
      References
      ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.
      Product Information
      CAS number121268-17-5
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₄H₁₂NNaO₇P₂ • 3H₂O
      Chemical formulaC₄H₁₂NNaO₇P₂ • 3H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetFarnesyl diphosphate synthase
      Primary Target IC<sub>50</sub>460 nM against farnesyl diphosphate synthase; ~ 40 - 70 µM as as a broad-spectrum MMP inhibitor; ~ 1 pM against in vitro invasion of prostate cancer cells
      Purity≥98% by titration
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSSZ6523500
      Safety Information
      R PhraseR: 22;
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      126855-100MG 04055977222142

      Documentation

      Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Alendronate, Sodium Salt - CAS 121268-17-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      126855

      Références bibliographiques

      Aperçu de la référence bibliographique
      Lehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision10-April-2008 RFH
      SynonymsAlendronate, Sodium, Trihydrate, 4-Amino-1-hydroxybutylidine-1,1-bisphosphonate
      DescriptionAn amino-bisphosphonate that acts as a potent inhibitor of bone resorption and cartilage destruction. Causes disruption of the ruffled border and actin cytoskeleton of osteoclasts. Shown to induce apoptosis of osteoclasts and macrophages. Inhibits farnesyl disphosphate synthase (IC50 = 460 nM with purified enzyme and 1.7 µM with cell extracts). Also shown to inhibit migration, cell adhesion, and invasion of cells (IC50 = 1 pM in prostate cancer cell invasion assays). Efficiently chelates metal ions and functions as a matrix metalloprotease (MMP) inhibitor (IC50 = 40-70 µM).
      FormWhite solid
      CAS number121268-17-5
      RTECSSZ6523500
      Chemical formulaC₄H₁₂NNaO₇P₂ • 3H₂O
      Structure formulaStructure formula
      Purity≥98% by titration
      SolubilityH₂O (10 mg/ml)
      Storage +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      Merck USA index14, 229
      ReferencesLehenkari, P.P., et al. 2002. Mol. Pharmacol. 62, 1255.
      Virtanen, S.S., et al. 2002. Cancer Res. 62, 2708.
      Bergstrom, J.D., et al. 2000. Arch. Biochem. Biophys. 373, 231.
      Smith, R., et al. 1971. Lancet 1, 945.
      Fleisch, H., et al. 1969. Nature 223, 211.