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658425 AG 17 - CAS 10537-47-0 - Calbiochem

Anti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC₅₀ = 500 nM).

AG 17 - CAS 10537-47-0 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: NSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872

Primary Target: Platelet-derived growth factor receptor tyrosine kinase
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658425
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Tableau de caractéristiques principal

CAS #Empirical Formula
10537-47-0C₁₈H₂₂N₂O

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658425-5MG
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      Description
      OverviewAnti-proliferative agent that acts as a selective inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). A potent, cell-permeable, reversible, and substrate competitive inhibitor of TNF-induced tyrosine phosphorylation of PYK2. Uncouples oxidative phosphorylation and induces apoptosis and cell growth arrest in NHL cell lines. Inhibits Cdk2 activity in lymphoma cell lines.
      Catalogue Number658425
      Brand Family Calbiochem®
      SynonymsNSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
      References
      ReferencesFuortes, M., et al. 1999. J. Clin. Invest. 104, 327.
      Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434.
      Burger, A.M., et al. 1995. Cancer Res. 55, 2794.
      Palumbo, G.A., et al. 1994. Blood 84, 296a.
      Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
      Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171.
      Terada, H. 1981. Biochim. Biophys. Acta 639, 225
      Product Information
      CAS number10537-47-0
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₁₈H₂₂N₂O
      Chemical formulaC₁₈H₂₂N₂O
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPlatelet-derived growth factor receptor tyrosine kinase
      Primary Target IC<sub>50</sub>500 nM against platelet-derived growth factor receptor tyrosine kinase
      Purity≥99% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSOO3737000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      658425-5MG 04055977261615

      Documentation

      AG 17 - CAS 10537-47-0 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      AG 17 - CAS 10537-47-0 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      658425

      Références bibliographiques

      Aperçu de la référence bibliographique
      Fuortes, M., et al. 1999. J. Clin. Invest. 104, 327.
      Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434.
      Burger, A.M., et al. 1995. Cancer Res. 55, 2794.
      Palumbo, G.A., et al. 1994. Blood 84, 296a.
      Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
      Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171.
      Terada, H. 1981. Biochim. Biophys. Acta 639, 225

      Brochure

      Titre
      Caspases and other Apoptosis Related Tools Brochure
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-January-2010 RFH
      SynonymsNSC 242557, 3,5-di-t-Butyl-4-hydroxy-benzylidenemalononitrile, α-Cyano-(3,5-di-t-butyl-4-hydroxy)cinnamonitrile, Tyrphostin A9, RG 50872
      DescriptionA selective, cell-permeable, reversible, and substrate competitive inhibitor of the platelet-derived growth factor receptor tyrosine kinase (IC50 = 500 nM). Anti-proliferative agent. Uncoupler of oxidative phosphorylation. Induces apoptosis in vitro and cell growth arrest in NHL cell lines.
      FormPale yellow solid
      CAS number10537-47-0
      RTECSOO3737000
      Chemical formulaC₁₈H₂₂N₂O
      Structure formulaStructure formula
      Purity≥99% by TLC
      SolubilityDMSO (10 mg/ml) or Ethanol (5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Toxic
      ReferencesFuortes, M., et al. 1999. J. Clin. Invest. 104, 327.
      Palumbo, G.A., et al. 1997. Cancer Res. 57, 2434.
      Burger, A.M., et al. 1995. Cancer Res. 55, 2794.
      Palumbo, G.A., et al. 1994. Blood 84, 296a.
      Bilder, G.E., et al. 1991. Am. J. Physiol. 260, C721.
      Levitzki, A., and Gilon, S. 1991. Trends Pharmacol. Sci. 12, 171.
      Terada, H. 1981. Biochim. Biophys. Acta 639, 225