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100109 AACOCF₃ - CAS 149301-79-1 - Calbiochem

A cell-permeable trifluoromethyl ketone analog of arachidonic acid.

AACOCF₃ - CAS 149301-79-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: Arachidonyltrifluoromethyl Ketone, cPLA2α Inhibitor II

Primary Target: cPLA2
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      149301-79-1C₂₁H₃₁F₃O
      Description
      OverviewA cell-permeable trifluoromethyl ketone analog of arachidonic acid. Potent and selective slow-binding inhibitor of cytosolic (85 kDa) phospholipase A2 (cPLA2; IC50 = ~20 µM). Specific inhibition of cPLA2 activity by AACOCF3 partially inhibits TNF-induced apoptosis without inhibition of caspase activity. Causes a significant diminution in thromboxane B2 production in thrombin-stimulated platelets. Also inhibits platelet aggregation in response to collagen and arachidonic acid.
      Catalogue Number100109
      Brand Family Calbiochem®
      SynonymsArachidonyltrifluoromethyl Ketone, cPLA2α Inhibitor II
      References
      ReferencesAlmeida T., et al. 1999. Brain Res. 826, 104.
      Kuwata, H., et al. 1998. J. Biol. Chem. 273, 1733.
      Wissing, D., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 5073.
      McNicol, A., and Nickolaychuk, B.R. 1995. Biochem. Pharmacol. 50, 1795.
      Bartoli, F., et al. 1994. J. Biol. Chem. 269, 15625.
      Street, I.P., et al. 1993. Biochemistry 32, 5935.
      Product Information
      CAS number149301-79-1
      ATP CompetitiveN
      FormClear yellow oil
      Hill FormulaC₂₁H₃₁F₃O
      Chemical formulaC₂₁H₃₁F₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetcPLA2
      Primary Target IC<sub>50</sub>20 µM inhibiting cytosolic (85 kDa) phospholipase A2 (cPLA2)
      Purity≥97% by TLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 11

      Highly flammable.
      S PhraseS: 16-7

      Keep away from sources of ignition - No Smoking.
      Keep container tightly closed.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Flammable
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for 1-2 months at -20°C or -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      100109 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Références bibliographiques

      Aperçu de la référence bibliographique
      Almeida T., et al. 1999. Brain Res. 826, 104.
      Kuwata, H., et al. 1998. J. Biol. Chem. 273, 1733.
      Wissing, D., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 5073.
      McNicol, A., and Nickolaychuk, B.R. 1995. Biochem. Pharmacol. 50, 1795.
      Bartoli, F., et al. 1994. J. Biol. Chem. 269, 15625.
      Street, I.P., et al. 1993. Biochemistry 32, 5935.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision18-August-2011 JSW
      SynonymsArachidonyltrifluoromethyl Ketone, cPLA2α Inhibitor II
      DescriptionA cell-permeable trifluoromethyl ketone analog of arachidonic acid. Potent and selective slow-binding inhibitor of human cytosolic (85 kDa) phospholipase A2 (PLA2). Causes a significant reduction in thromboxane B2 production in thrombin-stimulated platelets.
      FormClear yellow oil
      Intert gas (Yes/No) Packaged under inert gas
      CAS number149301-79-1
      Chemical formulaC₂₁H₃₁F₃O
      Structure formulaStructure formula
      Purity≥97% by TLC
      SolubilityDMSO (10 mg/ml) or Ethanol (50 mg/ml)
      Storage Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C or -70°C). Stock solutions are stable for 1-2 months at -20°C or -70°C.
      Toxicity Flammable
      ReferencesAlmeida T., et al. 1999. Brain Res. 826, 104.
      Kuwata, H., et al. 1998. J. Biol. Chem. 273, 1733.
      Wissing, D., et al. 1997. Proc. Natl. Acad. Sci. USA 94, 5073.
      McNicol, A., and Nickolaychuk, B.R. 1995. Biochem. Pharmacol. 50, 1795.
      Bartoli, F., et al. 1994. J. Biol. Chem. 269, 15625.
      Street, I.P., et al. 1993. Biochemistry 32, 5935.