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407900 5-Iodotubercidin

5-Iodotubercidin : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, ITU

407900
  
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      Aperçu

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, potent and competitive inhibitor of the MAP kinase ERK2 (Ki = 530 nM). Also inhibits adenosine kinase (Ki = 30 nM), serine/threonine kinases such as casein kinase I and PKA, and the insulin receptor kinase fragment (IC50 = 0.4-28 µM).
      Catalogue Number407900
      Brand Family Calbiochem®
      Synonyms4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, ITU
      References
      ReferencesFox, T., et al. 1998. Protein Science 7, 2249.
      Parkinson, F.E., et al. 1996. J. Pharmacol. Exp. Ther. 277, 1397.
      Massillon, D., et al. 1994. Biochem. J. 299, 123.
      Cottam, H.B., et al. 1993. J. Med. Chem. 36, 3424.
      Newby, A.C., et al. 1993. Biochem. J. 214, 317.
      Product Information
      CAS number24386-93-4
      FormTan solid
      Hill FormulaC₁₁H₁₃IN₄O₄
      Chemical formulaC₁₁H₁₃IN₄O₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetERK2
      Primary Target K<sub>i</sub>530 nM
      Secondary targetadenosine kinase (IC₅₀ = 30 nM)
      Purity≥90% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      407900 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      5-Iodotubercidin Certificats d'analyse

      TitreNuméro de lot
      407900

      Références bibliographiques

      Aperçu de la référence bibliographique
      Fox, T., et al. 1998. Protein Science 7, 2249.
      Parkinson, F.E., et al. 1996. J. Pharmacol. Exp. Ther. 277, 1397.
      Massillon, D., et al. 1994. Biochem. J. 299, 123.
      Cottam, H.B., et al. 1993. J. Med. Chem. 36, 3424.
      Newby, A.C., et al. 1993. Biochem. J. 214, 317.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-January-2010 RFH
      Synonyms4-Amino-5-iodo-7-(β-D-ribofuranosyl)pyrrolo[2,3-d]pyrimidine, ITU
      DescriptionA cell-permeable potent inhibitor of adenosine kinase (Ki = 30 nM) and Ser/Thr-specific kinases, such as casein kinases 1 and protein kinase A (CKI and PKA), and the insulin receptor kinase fragment (IC50 values range from 0.4-28 µM). Also shown to be a potent, and competitive inhibitor of the MAP kinase ERK2 (Ki = 530 nM).
      FormTan solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number24386-93-4
      Chemical formulaC₁₁H₁₃IN₄O₄
      Structure formulaStructure formula
      Purity≥90% by HPLC
      SolubilityDMSO (35 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFox, T., et al. 1998. Protein Science 7, 2249.
      Parkinson, F.E., et al. 1996. J. Pharmacol. Exp. Ther. 277, 1397.
      Massillon, D., et al. 1994. Biochem. J. 299, 123.
      Cottam, H.B., et al. 1993. J. Med. Chem. 36, 3424.
      Newby, A.C., et al. 1993. Biochem. J. 214, 317.