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504317 5-Azacytidine - CAS 320-67-2 - Calbiochem

5-Azacytidine - CAS 320-67-2 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, 5'AzaC, 5-Azacitidine, Zcyd

Primary Target: DNA & RNA
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      320-67-2C₈H₁₂N₄O₅
      Description
      Overview

      This product has been discontinued.



      A cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50 < 4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).
      Catalogue Number504317
      Brand Family Calbiochem®
      Synonyms4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, 5'AzaC, 5-Azacitidine, Zcyd
      References
      ReferencesHollenbach, P.W., et al. 2010. PLoS ONE 5, e9001.Nature 454, 49.
      Huangfu, D., et al. 2008. Nat. Biotech. 26, 795.
      Christman, J.K., 2002. Oncogene 21, 5483.
      Product Information
      CAS number320-67-2
      FormOff-white powder
      Hill FormulaC₈H₁₂N₄O₅
      Chemical formulaC₈H₁₂N₄O₅
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetDNA & RNA
      Purity≥93% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 45-46

      May cause cancer.
      May cause heritable genetic damage.
      S PhraseS: 22-36/37/39

      Do not breathe dust.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsUnstable in H₂O. Following reconstitution, store at 4°C for <12 hr.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      504317 0

      Documentation

      5-Azacytidine - CAS 320-67-2 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Hollenbach, P.W., et al. 2010. PLoS ONE 5, e9001.Nature 454, 49.
      Huangfu, D., et al. 2008. Nat. Biotech. 26, 795.
      Christman, J.K., 2002. Oncogene 21, 5483.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-July-2013 JSW
      Synonyms4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one, 5'AzaC, 5-Azacitidine, Zcyd
      DescriptionA cell-permeable ribonucleoside analog of cytidine that is reported to readily incorporate into RNA and DNA, and inhibit protein synthesis. Causes DNA methyltransferases depletion, DNA hypomethylation and DNA damage. Selectively activates eukaryotic gene expression, and potently arrests the growth of several AML cells (EC50 < 4.0 µM). Enhances reprogramming efficiency (EC50 ~ 2.4 µM in iOSKM-MEFs). 5-Aza-2′-Deoxycytidine (ZaCyd) is also available (Cat. No. 189825) & (Cat. No. 189826).
      FormOff-white powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number320-67-2
      Chemical formulaC₈H₁₂N₄O₅
      Structure formulaStructure formula
      Purity≥93% by HPLC
      SolubilityDMSO (100 mg/ml) or H₂O (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in H₂O. Following reconstitution, store at 4°C for <12 hr.
      Toxicity Toxic & Carcinogenic / Teratogenic
      ReferencesHollenbach, P.W., et al. 2010. PLoS ONE 5, e9001.Nature 454, 49.
      Huangfu, D., et al. 2008. Nat. Biotech. 26, 795.
      Christman, J.K., 2002. Oncogene 21, 5483.