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393204 4-Hydroxynonenal - CAS 75899-68-2 - Calbiochem

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CAS #Empirical Formula
75899-68-2C₉H₁₆O₂

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393204-1MG
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      Description
      OverviewA major aldehyde product formed by peroxidation of ω-6-unsaturated fatty acids that is regarded as a specific marker of lipid peroxidation. Inhibits proliferation and induces differentiation of HL-60 human leukemic cells. Also induces cell death in murine alveolar macrophages and in PC12 cells. An inhibitor of state 3 respiration at micromolar levels. Causes a transient increase in cytosolic Ca2+ and irreversibly inhibits Na+, K+-ATPase activity (IC50 = 120 µM). Acts as a reversible inhibitor of c-Jun N-terminal kinase (JNK).
      Catalogue Number393204
      Brand Family Calbiochem®
      SynonymsHNE, 4-Hydroxy-2-nonenal
      References
      ReferencesSoh, Y., et al. 2000. Mol. Pharmacol. 58, 535.
      Carini, R., et al. 1996. Biochem. Biophys. Res. Commun. 218, 772.
      Li, L., et al. 1996. Toxicol. Appl. Pharmacol. 139, 135.
      Siems, W.G., et al. 1996. Free Radic. Res. 20, 215.
      Ullrich, O., et al. 1996. Free Radic. Res. 24, 421.
      van Kuijk, F.J., et al. 1995. Anal. Biochem. 224, 420.
      Esterbauer, H., et al. 1991. Free Radic. Biol. Med. 11, 81.
      Product Information
      CAS number75899-68-2
      ATP CompetitiveN
      FormLiquid
      FormulationSupplied at 10 mg/ml in ethanol
      Hill FormulaC₉H₁₆O₂
      Chemical formulaC₉H₁₆O₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetNa+, K+-ATPase activity
      Primary Target IC<sub>50</sub>120 µM against Na+, K+-ATPase activity
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Safety Information according to GHS
      RTECSRA8510000
      Safety Information
      R PhraseR: 11

      Highly flammable.
      S PhraseS: 7-16

      Keep container tightly closed.
      Keep away from sources of ignition - No Smoking.
      Storage and Shipping Information
      Toxicity Flammable
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Global Trade Item Number
      Référence GTIN
      393204-1MG 04055977212471