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504472 (2R,4R)-APDC - CAS 169209-63-6 - Calbiochem

(2R,4R)-APDC - CAS 169209-63-6 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate, APDC

Primary Target: mGlu₂ and mGlu₃
504472
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Tableau de caractéristiques principal

CAS #Empirical Formula
169209-63-6C₆H₁₀N₂O₄

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      Description
      OverviewA highly selective and potent agonist for group II metabotropic glutamate receptor (EC50 = 0.4, 0.4, > 100, > 100, > 300 and > 300 µM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively). Used as anti- and pro-convulsant, neuroprotectant, antinociceptive, and addiction treatment.
      Catalogue Number504472
      Brand Family Calbiochem®
      Synonyms(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate, APDC
      References
      ReferencesFolbergrová, J., et al. 2005. Experimental Neurology. 192, 420.
      Fisher, K., et al. 2002. Pharmacol. Bioche. and Behav. 73, 411.
      Schoepp, D., et al. 1995. Neuropharmacology. 34, 843.
      Monn, J., et al. 1996. J. Med. Chem. 39, 2990.
      Product Information
      CAS number169209-63-6
      FormOff-white powder
      Hill FormulaC₆H₁₀N₂O₄
      Chemical formulaC₆H₁₀N₂O₄
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary TargetmGlu₂ and mGlu₃
      Purity≥98% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.04472.0001 04055977264142

      Documentation

      (2R,4R)-APDC - CAS 169209-63-6 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Folbergrová, J., et al. 2005. Experimental Neurology. 192, 420.
      Fisher, K., et al. 2002. Pharmacol. Bioche. and Behav. 73, 411.
      Schoepp, D., et al. 1995. Neuropharmacology. 34, 843.
      Monn, J., et al. 1996. J. Med. Chem. 39, 2990.

      Brochure

      Titre
      Pathways and Biomarkers of Glutamatergic Synapse Flyer
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision07-August-2017 JSW
      Synonyms(2R,4R)-4-Aminopyrrolidine-2,4-dicarboxylate, APDC
      DescriptionA highly selective and potent agonist for group II metabotropic glutamate receptor (EC50 = 0.4, 0.4, > 100, > 100, > 300 and > 300 µM for human mGlu2, mGlu3, mGlu1, mGlu5, mGlu4 and mGlu7 receptors respectively). Used as anti- and pro-convulsant, neuroprotectant, antinociceptive, and addiction treatment.
      FormOff-white powder
      CAS number169209-63-6
      Chemical formulaC₆H₁₀N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFolbergrová, J., et al. 2005. Experimental Neurology. 192, 420.
      Fisher, K., et al. 2002. Pharmacol. Bioche. and Behav. 73, 411.
      Schoepp, D., et al. 1995. Neuropharmacology. 34, 843.
      Monn, J., et al. 1996. J. Med. Chem. 39, 2990.