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505419 α,β-methylene ATP - CAS 104809-20-3 - Calbiochem

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Synonymes: αβ-MeATP, αβ-methylene ATP, P2X purinergic receptor agonist, α,β-methylene ATP, α,β-Methyleneadenosine 5ʹ-triphosphate lithium salt

Primary Target: P2X
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505419
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Tableau de caractéristiques principal

CAS #Empirical Formula
104809-20-3C₁₁H₁₈N₅O₁₂P₃ • xLi+

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      Description
      OverviewA metabolically stable and selective P2X purinergic receptor agonist (pEC50 = 5.81) that is shown to be more potent than ATP. Elicits contractions in ileum through the release of endogenous acetylcholine, which can be blocked by tetrodotoxin (~1 mM). Shown to depolarize cells of the longitudinal muscle strips (~ 200 nM to 4 µM) that reaches a peak within 2-3 min after application and then decays to a steady level.
      Catalogue Number505419
      Brand Family Calbiochem®
      Synonymsαβ-MeATP, αβ-methylene ATP, P2X purinergic receptor agonist, α,β-methylene ATP, α,β-Methyleneadenosine 5ʹ-triphosphate lithium salt
      References
      ReferencesSawyer, G.W., et al. 2000. Br. J. Pharmacol. 129, 1458.
      Komori, S., et al. 1988. Br. J. Pharmacol. 94, 9.
      Product Information
      CAS number104809-20-3
      FormWhite powder
      Hill FormulaC₁₁H₁₈N₅O₁₂P₃ • xLi+
      Chemical formulaC₁₁H₁₈N₅O₁₂P₃ • xLi+
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetP2X
      Purity≥93% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      5.05419.0001 04055977243833

      Documentation

      α,β-methylene ATP - CAS 104809-20-3 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      Références bibliographiques

      Aperçu de la référence bibliographique
      Sawyer, G.W., et al. 2000. Br. J. Pharmacol. 129, 1458.
      Komori, S., et al. 1988. Br. J. Pharmacol. 94, 9.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision30-October-2023 JSW
      Synonymsαβ-MeATP, αβ-methylene ATP, P2X purinergic receptor agonist, α,β-methylene ATP, α,β-Methyleneadenosine 5ʹ-triphosphate lithium salt
      DescriptionA metabolically stable and selective P2X purinergic receptor agonist (pEC50 = 5.81) that is shown to be more potent than ATP. Elicits contractions in ileum through the release of endogenous acetylcholine, which can be blocked by tetrodotoxin (~1 mM). Shown to depolarize cells of the longitudinal muscle strips (~ 200 nM to 4 µM) that reaches a peak within 2-3 min after application and then decays to a steady level.
      FormWhite powder
      CAS number104809-20-3
      Chemical formulaC₁₁H₁₈N₅O₁₂P₃ • xLi+
      Structure formulaStructure formula
      Purity≥93% by HPLC
      SolubilityH₂O (100 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesSawyer, G.W., et al. 2000. Br. J. Pharmacol. 129, 1458.
      Komori, S., et al. 1988. Br. J. Pharmacol. 94, 9.