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585970 (±)-Thalidomide - CAS 50-35-1 - Calbiochem

Selective inhibitor of TNF-α biosynthesis.

(±)-Thalidomide - CAS 50-35-1 - Calbiochem : FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.

Synonymes: (±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione

Primary Target: TNF-α biosynthesis
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      Aperçu

      Replacement Information

      Tableau de caractéristiques principal

      CAS #Empirical Formula
      50-35-1C₁₃H₁₀N₂O₄
      Description
      OverviewSelective inhibitor of TNF-α biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.
      Catalogue Number585970
      Brand Family Calbiochem®
      Synonyms(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
      References
      ReferencesGershon, D. 1995. Nat. Med. 1, 1230.
      Thompson, C. 1995. Lancet 346, 1289.
      Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
      D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.
      Product Information
      CAS number50-35-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₃H₁₀N₂O₄
      Chemical formulaC₁₃H₁₀N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetTNF-α biosynthesis
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableN
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSTI4375000
      Safety Information
      R PhraseR: 21-25-46-61-62

      Harmful in contact with skin.
      Toxic if swallowed.
      May cause heritable genetic damage.
      May cause harm to the unborn child.
      Possible risk of impaired fertility.
      S PhraseS: 36/37/39-45-22-26

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Do not breathe dust.
      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic & Carcinogenic / Teratogenic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage +15°C to +30°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      585970 0

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      (±)-Thalidomide - CAS 50-35-1 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      (±)-Thalidomide - CAS 50-35-1 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      585970

      Références bibliographiques

      Aperçu de la référence bibliographique
      Gershon, D. 1995. Nat. Med. 1, 1230.
      Thompson, C. 1995. Lancet 346, 1289.
      Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
      D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision13-February-2014 JSW
      Synonyms(±)-2-(2,6-Dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione
      DescriptionSelective inhibitor of TNFα biosynthesis. Blocks basic fibroblast growth factor (bFGF)-induced angiogenesis in cornea. An immunomodulator that inhibits replication of the HIV-1 virus. Has been used to treat AIDS-related oral ulcers.
      FormWhite solid
      CAS number50-35-1
      RTECSTI4375000
      Chemical formulaC₁₃H₁₀N₂O₄
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage +15°C to +30°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze(-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Toxic & Carcinogenic / Teratogenic
      Merck USA index14, 9255
      ReferencesGershon, D. 1995. Nat. Med. 1, 1230.
      Thompson, C. 1995. Lancet 346, 1289.
      Tramontana, J.M., et al. 1995. Mol. Med. 1, 384.
      D’Amato, R.J., et al. 1994. Proc. Natl. Acad. Sci. USA 91, 4082.