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203390 (±)-Blebbistatin - CAS 674289-55-5 - Calbiochem

(±)-Blebbistatin, CAS 674289-55-5, is a cell-permeable, selective, and reversible inhibitor of nonmuscle myosin II. Blocks cell blebbing and disrupts cell migration & cytoKinesis in vertebrate cells.

FDS (Fiches de données de sécurité), certificats d’analyse (CoA) et de qualité (CoQ), dossiers, brochures et autres documents disponibles.
Primary Target: ATPase
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203390
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Tableau de caractéristiques principal

CAS #Empirical Formula
674289-55-5C₁₈H₁₆N₂O₂

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203390-5MG
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      		 Ampoule plast. 5 mg
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      Description
      OverviewA cell-permeable compound that acts as a selective, potent, and reversible inhibitor of nonmuscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤ 100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly. A 50 mM (5 mg/342 µl) solution of (±)-Blebbistatin (Cat. No. 203389) in 90% DMSO is also available.
      Catalogue Number203390
      Brand Family Calbiochem®
      References
      ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
      Product Information
      CAS number674289-55-5
      ATP CompetitiveN
      FormYellow solid
      Hill FormulaC₁₈H₁₆N₂O₂
      Chemical formulaC₁₈H₁₆N₂O₂
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetATPase
      Primary Target IC<sub>50</sub><100 µM inhibiting the ATPase and gliding motility of human platelets
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution in 90% DMSO, aliquot and freeze (-20°C). Stock solutions in 90% DMSO are stable for up to 1 month at -20°C. Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Référence GTIN
      203390-5MG 04055977221268

      Documentation

      Required Licenses

      Title
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      (±)-Blebbistatin - CAS 674289-55-5 - Calbiochem FDS

      Titre

      Fiche de données de sécurité des matériaux (FDS) 

      (±)-Blebbistatin - CAS 674289-55-5 - Calbiochem Certificats d'analyse

      TitreNuméro de lot
      203390

      Références bibliographiques

      Aperçu de la référence bibliographique
      Shu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.
      Fiche technique

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision31-March-2011 RFH
      DescriptionA cell-permeable compound that acts as a selective, potent, and reversible inhibitor of non-muscle myosin II. Inhibits the ATPase and gliding motility of human platelets (≤100 µM) without affecting myosin light chain kinase (MLCK) activity. Has been shown to block cell blebbing and to rapidly disrupt directed cell migration and cytokinesis in vertebrate cells. Does not disrupt mitosis or affect contractile ring assembly.
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number674289-55-5
      Chemical formulaC₁₈H₁₆N₂O₂
      Structure formulaStructure formula
      Purity≥97% by HPLC
      Solubility100% DMSO (100 mg/ml), 90% DMSO (75 mg/ml) or Methanol (1.5 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution in 90% DMSO, aliquot and freeze (-20°C). Stock solutions in 90% DMSO are stable for up to 1 month at -20°C. Stock solutions in 100% DMSO are unstable; reconstitute just prior to use.
      ReferencesShu, S., et al. 2005. Proc. Natl. Acad. Sci. USA 102, 1472.
      Kovacs, M., et al. 2004. J. Biol. Chem. 279, 35557.
      Straight, A.F., et al. 2003. Science 299, 1743.
      Cheung, A., et al. 2001. Mol. Biol. Cell Suppl. 12, 271a.