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506165 p53, His•Tag®, Human, Recombinant, E. coli

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Tumor Protein p53

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      Descripción

      Replacement Information
      Description
      Overview

      This product has been discontinued.



      Recombinant, human, wild-type p53 fused at the N-terminus to a His•Tag® sequence and expressed in E. coli. p53, a tumor suppressor, blocks transformation and inhibits tumor cell growth. Numerous mutations in the p53 gene have been characterized in human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis. The purified protein is useful in DNA binding assays and as a protein kinase substrate.
      Catalogue Number506165
      Brand Family Calbiochem®
      SynonymsTumor Protein p53
      References
      ReferencesLiu, G., et al. 2003. J. Biol. Chem. 278, 17557.
      Zhang, L., et al. 2000. Cancer Res. 60, 3655.
      Fields, S., and Jang, S.K. 1990. Science 249, 1046.
      Michalovitz, D., et al. 1990. Cell 62, 671.
      Raycroft, L., et al. 1990. Science 249, 1049.
      Finlay, C.A., et al. 1989. Cell 57, 1083.
      Product Information
      FormLiquid
      FormulationIn 50 mM KCl, 30 mM sodium pyrophosphate, 5% glycerol, pH 7.5.
      Quality LevelMQ100
      Applications
      Biological Information
      Biological activityTypical DNA binding assays require 0.5 ng to 2 ng of p53 protein per assay.
      Purity≥80% by SDS-PAGE
      Concentration Label Please refer to vial label for lot-specific concentration
      Physicochemical Information
      ContaminantsProteases: none detected
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Dry Ice Only
      Toxicity Standard Handling
      Storage ≤ -70°C
      Avoid freeze/thaw Avoid freeze/thaw
      Do not freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      506165 0

      Documentation

      p53, His•Tag®, Human, Recombinant, E. coli Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      p53, His•Tag®, Human, Recombinant, E. coli Certificados de análisis

      CargoNúmero de lote
      506165

      Referencias bibliográficas

      Visión general referencias
      Liu, G., et al. 2003. J. Biol. Chem. 278, 17557.
      Zhang, L., et al. 2000. Cancer Res. 60, 3655.
      Fields, S., and Jang, S.K. 1990. Science 249, 1046.
      Michalovitz, D., et al. 1990. Cell 62, 671.
      Raycroft, L., et al. 1990. Science 249, 1049.
      Finlay, C.A., et al. 1989. Cell 57, 1083.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-March-2009 JSW
      SynonymsTumor Protein p53
      DescriptionRecombinant, human, wild-type p53 fused at the N-terminus to a His•Tag® sequence and expressed in E. coli. p53, a tumor suppressor, blocks transformation and inhibits tumor cell growth. Numerous mutations in the p53 gene have been characterized in human cancers. Loss or mutation of p53 function is highly correlated with tumorigenesis. The purified protein is useful in DNA binding assays and as a protein kinase substrate.
      FormLiquid
      FormulationIn 50 mM KCl, 30 mM sodium pyrophosphate, 5% glycerol, pH 7.5.
      Concentration Label Please refer to vial label for lot-specific concentration
      Purity≥80% by SDS-PAGE
      ContaminantsProteases: none detected
      Biological activityTypical DNA binding assays require 0.5 ng to 2 ng of p53 protein per assay.
      Storage Avoid freeze/thaw
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
      Toxicity Standard Handling
      ReferencesLiu, G., et al. 2003. J. Biol. Chem. 278, 17557.
      Zhang, L., et al. 2000. Cancer Res. 60, 3655.
      Fields, S., and Jang, S.K. 1990. Science 249, 1046.
      Michalovitz, D., et al. 1990. Cell 62, 671.
      Raycroft, L., et al. 1990. Science 249, 1049.
      Finlay, C.A., et al. 1989. Cell 57, 1083.