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506153 p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem

The p38 MAP Kinase Inhibitor IV, also referenced under CAS 1638-41-1, controls the biological activity of p38 MAP Kinase. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 2,2ʹ-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4

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506153
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
1638-41-1C₁₂H₄Cl₆O₄S

Precios y disponibilidad

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506153-10MG
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      Description
      OverviewA cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).
      Catalogue Number506153
      Brand Family Calbiochem®
      Synonyms2,2ʹ-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4
      References
      ReferencesLiu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun. 352, 656.
      Product Information
      CAS number1638-41-1
      FormLight yellow solid
      Hill FormulaC₁₂H₄Cl₆O₄S
      Chemical formulaC₁₂H₄Cl₆O₄S
      Hygroscopic Hygroscopic
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 22-37/38-41

      Harmful if swallowed.
      Irritating to respiratory system and skin.
      Risk of serious damage to eyes.
      S PhraseS: 26-39

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Wear eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      506153-10MG 04055977272239

      Documentation

      p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      p38 MAP Kinase Inhibitor IV - CAS 1638-41-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      506153

      Referencias bibliográficas

      Visión general referencias
      Liu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun. 352, 656.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision21-May-2009 RFH
      Synonyms2,2ʹ-Sulfonyl-bis-(3,4,6-trichlorophenol), MT4
      DescriptionA cell-permeable symmetrical sulfone compound that acts as a potent and ATP-competitive inhibitor of p38α/β MAPK (IC50 = 130 and 550 nM, respectively), while exihibiting much reduced activity (≤23% inhibition at 1 µM) against p38γ/δ, ERK1/2, and JNK1/2/3. Shown to be more effective than SB 203850 (Cat. Nos. 559389, 559395, and 559398) in inhibiting LPS-induced IL-1β release from hPBMC (100% vs. 50% inhibition with 100 µM respective inhibitor).
      FormLight yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number1638-41-1
      Chemical formulaC₁₂H₄Cl₆O₄S
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (4.5 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Harmful
      ReferencesLiu, Y.C., et al. 2007. Biochem. Biophys. Res. Commun. 352, 656.