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14-654M eEF-2K Protein, active, 250 µg

Active, N-terminal GST-tagged, recombinant, human eEF-2K, amino acids 2-end, for use in Kinase Assays.

14-654M
250 µg  Also available in 10 μg size (cat#14-654) and in bulk (cat#14-654-K).
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-654M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptioneEF-2K Protein, active, 250 µg
      OverviewN-terminal GST-tagged, recombinant, human eEF-2K, amino acids 2-end
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal GST-tagged, recombinant, human eEF-2K, amino acids 2-end, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed in E. coli cells
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a highly conserved protein kinase in the calmodulin-mediated signaling pathway that links activation of cell surface receptors to cell division. This kinase is involved in the regulation of protein synthesis. It phosphorylates eukaryotic elongation factor 2 (EEF2) and thus inhibits the EEF2 function. The activity of this kinase is increased in many cancers and may be a valid target for anti-cancer treatment.
      Gene Symbol
      • EEF2K
      • MGC45041
      • HSU93850
      • eEF-2K
      Protein TargeteEF-2K
      Purification MethodGlutathione-agarose
      Target Sub-FamilyMisc
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: O00418 # Phosphorylates eukaryotic elongation factor-2. Binds calmodulin (By similarity).
      SIZE: 725 amino acids; 82172 Da
      SUBUNIT: Monomer or homodimer (Potential).
      SIMILARITY: SwissProt: O00418 ## Contains 1 alpha-type protein kinase domain.
      Molecular Weight108.5kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of EF2tide (Catalog# 12-560)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable 6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-654) and in bulk (cat#14-654-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-654M 04053252924606

      Documentation