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344037 cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem

The cFMS Receptor Inhibitor II, also referenced under CAS 959860-85-6, controls the biological activity of cFMS. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 4-(3,4-Dimethylanilino)-7-(4-pyridyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor II

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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      959860-85-6C₂₃H₂₀N₄O
      Description
      OverviewA cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 80 nM). Although equally potent as cFMS Receptor Inhibitor III (Cat. No. 344038) in inhibiting the cFMS-dependent growth of M-NSF-60 cells (IC50 = 0.1 µM), this inhibitor is much more selective against cFMS-independent growth of NSO cells (IC50 >50 µM).
      Catalogue Number344037
      Brand Family Calbiochem®
      Synonyms4-(3,4-Dimethylanilino)-7-(4-pyridyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor II
      References
      ReferencesSmalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.
      Product Information
      CAS number959860-85-6
      FormYellow solid
      Hill FormulaC₂₃H₂₀N₄O
      Chemical formulaC₂₃H₂₀N₄O
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      S PhraseS: 22-24/25-36/37/39

      Do not breathe dust.
      Avoid contact with skin and eyes.
      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      344037 0

      Documentation

      cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      cFMS Receptor Inhibitor II - CAS 959860-85-6 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      344037

      Referencias bibliográficas

      Visión general referencias
      Smalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-May-2011 RFH
      Synonyms4-(3,4-Dimethylanilino)-7-(4-pyridyl)quinoline-3-carboxamide, CSF-1 Receptor Inhibitor II
      DescriptionA cell-permeable anilinoquinoline compound that acts as a potent, active site-targeting inhibitor of MCSF receptor/cFMS (IC50 = 80 nM). Although equally potent as cFMS Receptor Inhibitor III (Cat. No. 344038) in inhibiting the cFMS-dependent growth of M-NSF-60 cells (IC50 = 0.1 µM), this inhibitor is much more selective against cFMS-independent growth of NSO cells (IC50 >50 µM).
      FormYellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number959860-85-6
      Chemical formulaC₂₃H₂₀N₄O
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesSmalley, T.L. Jr., et al. 2007. Bioorg. Med. Chem. Lett. 17, 6257.