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691400 Zebularine - CAS 3690-10-6 - Calbiochem

A cell-permeable chemically stable cytidine analog that displays antitumor properties.

Zebularine - CAS 3690-10-6 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside

Primary Target: Cytidine deaminase
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691400
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
3690-10-6C₉H₁₂N₂O₅

Precios y disponibilidad

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691400-10MG
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      691400-25MG
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          Contact Customer Service

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          Description
          OverviewA cell-permeable chemically stable cytidine analog that displays antitumor properties. Acts as transition state analog inhibitor of cytidine deaminase by binding at the active site as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
          Catalogue Number691400
          Brand Family Calbiochem®
          Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
          References
          ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
          Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
          Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
          Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
          Frick, L., et al. 1989. Biochemistry 28, 9423.
          Product Information
          CAS number3690-10-6
          ATP CompetitiveN
          FormOff-white solid
          Hill FormulaC₉H₁₂N₂O₅
          Chemical formulaC₉H₁₂N₂O₅
          ReversibleN
          Structure formula ImageStructure formula Image
          Quality LevelMQ100
          Applications
          Biological Information
          Primary TargetCytidine deaminase
          Purity≥95% by HPLC
          Physicochemical Information
          Cell permeableY
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Safety Information
          Product Usage Statements
          Storage and Shipping Information
          Ship Code Blue Ice Only
          Toxicity Standard Handling
          Storage +2°C to +8°C
          Do not freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


          From Catalog:
          Desc. Field- added "cell-permeable
          Packaging Information
          Packaged under inert gas Packaged under inert gas
          Transport Information
          Supplemental Information
          Specifications
          Global Trade Item Number
          Número de referencia GTIN
          691400-10MG 04055977225105
          691400-25MG 04055977225112

          Documentation

          Zebularine - CAS 3690-10-6 - Calbiochem Ficha datos de seguridad (MSDS)

          Título

          Ficha técnica de seguridad del material (MSDS) 

          Zebularine - CAS 3690-10-6 - Calbiochem Certificados de análisis

          CargoNúmero de lote
          691400

          Referencias bibliográficas

          Visión general referencias
          Cheng, J.C., et al. 2004. Cancer Cell 6, 151.
          Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
          Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
          Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
          Frick, L., et al. 1989. Biochemistry 28, 9423.
          Ficha técnica

          Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

          Revision16-September-2008 RFH
          Synonyms1-(β-D-Ribofuranosyl)-1,2-dihydropyrimidin-2-one, 2-Pyrimidone-1-β-D-riboside
          DescriptionA chemically stable, cytidine analog that displays anti-tumor properties. Acts as a transition state analog inhibitor of cytidine deaminase by binding to the active size as covalent hydrates. Also shown to inhibit DNA methylation and tumor growth both in vitro and in vivo.
          FormOff-white solid
          Intert gas (Yes/No) Packaged under inert gas
          CAS number3690-10-6
          Chemical formulaC₉H₁₂N₂O₅
          Structure formulaStructure formula
          Purity≥95% by HPLC
          SolubilityDMSO (5 mg/ml) or Methanol (5 mg/ml). Slight warming may be required to achieve complete solubilization.
          Storage +2°C to +8°C
          Do Not Freeze Ok to freeze
          Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.


          From Catalog:
          Desc. Field- added "cell-permeable
          Toxicity Standard Handling
          ReferencesCheng, J.C., et al. 2004. Cancer Cell 6, 151.
          Cheng, J.C., et al. 2003. J. Natl. Cancer Inst. 95, 399.
          Zhou, L., et al. 2002. J. Mol. Biol. 321, 591.
          Barchi, J.J., Jr., et al. 1992. J. Org. Chem. 57, 536.
          Frick, L., et al. 1989. Biochemistry 28, 9423.