Millipore Sigma Vibrant Logo

681625 W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC₅₀ = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC₅₀ = 240 µM).

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: N-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl

Primary Target: Myosin light chain kinase (Mlck)
View Products on Sigmaaldrich.com
681625
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
61714-25-8C₁₆H₂₂N₂O₂S · HCl

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
681625-1MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 1 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      OverviewA cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).
      Catalogue Number681625
      Brand Family Calbiochem®
      SynonymsN-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
      References
      ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
      Product Information
      CAS number61714-25-8
      ATP CompetitiveN
      FormCrystalline solid
      Hill FormulaC₁₆H₂₂N₂O₂S · HCl
      Chemical formulaC₁₆H₂₂N₂O₂S · HCl
      Hygroscopic Hygroscopic
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMyosin light chain kinase (Mlck)
      Primary Target IC<sub>50</sub>230 µM and 240 µM against myosin light chain kinase and Ca2+-calmodulin-dependent phosphodiesterase, respectively.
      Purity≥98% by NMR
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      681625-1MG 04055977260137

      Documentation

      W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      W-5, Hydrochloride - CAS 61714-25-8 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      681625

      Referencias bibliográficas

      Visión general referencias
      Tanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision06-January-2010 RFH
      SynonymsN-(6-Aminohexyl)-1-naphthalenesulfonamide, HCl
      DescriptionA cell-permeable and reversible calmodulin antagonist that inhibits Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM) and myosin light chain kinase (IC50 = 230 µM).
      FormCrystalline solid
      CAS number61714-25-8
      Chemical formulaC₁₆H₂₂N₂O₂S · HCl
      Structure formulaStructure formula
      Purity≥98% by NMR
      SolubilityDMSO or H₂O
      Storage Protect from light
      +2°C to +8°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 6 months at 4°C.
      Toxicity Standard Handling
      ReferencesTanaka, T., et al. 1983. Pharmacol. 26, 249.
      Asano, M., et al. 1982. J. Pharmacol. Exp. Ther. 220, 191.
      Hidaka, H. 1981. Prot. Nuc. Acid Enz. 26, 977.
      Tanaka, T., and Hidaka, H. 1980. J. Biol. Chem. 255, 11078.

      Productos y aplicaciones relacionados

      Related Products

      Número de referencia Descripción  
      681629 W-7, Hydrochloride - CAS 61714-27-0 - Calbiochem Precios y disponibilidad
      681636 W-13, Hydrochloride - CAS 88519-57-7 - Calbiochem Precios y disponibilidad

      Categorías

      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Phosphodiesterase Inhibitors
      Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors