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579002 Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem

Tamoxifen, 4-Hydroxy-, (Z), CAS 68047-06-3, is a cell-permeable, active metabolite of Tamoxifen that is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: (Z)-4-Hydroxytamoxifen, 4-OH-TAM, Estrogen Receptor Signaling Regulator II

Primary Target: PKC
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      68047-06-3C₂₆H₂₉NO₂
      Description
      OverviewA cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain. Also available as a 10 mM solution in EtOH (Cat. No. 508225).
      Catalogue Number579002
      Brand Family Calbiochem®
      Synonyms(Z)-4-Hydroxytamoxifen, 4-OH-TAM, Estrogen Receptor Signaling Regulator II
      References
      ReferencesGundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.
      Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.
      Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.
      Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.
      Product Information
      CAS number68047-06-3
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₆H₂₉NO₂
      Chemical formulaC₂₆H₂₉NO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ200
      Applications
      ApplicationTamoxifen, 4-Hydroxy-, (Z), CAS 68047-06-3, is a cell-permeable, active metabolite of Tamoxifen that is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.
      Biological Information
      Primary TargetPKC
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSSL1210000
      Safety Information
      R PhraseR: 22-45-60-61-64

      Harmful if swallowed.
      May cause cancer.
      May impair fertility.
      May cause harm to the unborn child.
      May cause harm to breastfed babies.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Harmful & Carcinogenic / Teratogenic
      Storage +2°C to +8°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      579002 0

      Documentation

      Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Tamoxifen, 4-Hydroxy-, (Z)- - CAS 68047-06-3 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      579002

      Referencias bibliográficas

      Visión general referencias
      Gundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.
      Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.
      Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.
      Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision16-February-2012 RFH
      Synonyms(Z)-4-Hydroxytamoxifen, 4-OH-TAM, Estrogen Receptor Signaling Regulator II
      DescriptionA cell-permeable, active metabolite of Tamoxifen (Cat. No. 579000) that acts as a potent inhibitor of PKC. It is more potent than the parent compound and inhibits PKC by modifying its catalytic domain.
      FormWhite solid
      CAS number68047-06-3
      RTECSSL1210000
      Chemical formulaC₂₆H₂₉NO₂
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityEthanol (20 mg/ml, heating may be required) or Methanol (10 mg/ml)
      Storage +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Harmful & Carcinogenic / Teratogenic
      ReferencesGundimeda, U., et al. 1996. J. Biol. Chem. 271, 13504.
      Ye, Q. and Bodell, W.J. 1996. Carcinogenesis 17, 1747.
      Laser, R., et al. 1985. Eur. J. Cancer Clin. Oncol. 21, 985.
      Jordan, V.C., et al. 1978. J. Toxicol. Environ. Health 4, 364.