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573106 STAT3 Inhibitor X, HJB - Calbiochem

The STAT3 Inhibitor X, HJB controls the biological activity of STAT3.

STAT3 Inhibitor X, HJB - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 17-Hydroxy-jolkinolide B, HJB

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      Descripción

      Replacement Information

      Tabla espec. clave

      Empirical Formula
      C₂₀H₂₆O₅
      Description
      Overview

      This product has been discontinued.



      A diterpene diepoxide compound, which demonstrates high selectivity for the JAK/STAT3 signaling pathway and shows anti-tumor properties in certain human cancer cell lines at a concentration of ~12 µM. HJB suppresses IL-6-induced STAT-3 transcription activity (IC50= ˜ 3.34 µM) in HepG2 cells and inhibits IL-6-induced and constitutive STAT-3 tyrosine phosphorylation at a concentration of 10 µM in a select few human cancer cell lines. In HEK 293 culture, HJB hinders JAK kinase activity (IC50 <10 µM) and induces JAK dimerization via cross-linking at a concentration of 20 µM.
      Catalogue Number573106
      Brand Family Calbiochem®
      Synonyms17-Hydroxy-jolkinolide B, HJB
      References
      ReferencesWang, Y., et al. 2009, Canc. Res. 69, 7302.
      Product Information
      FormOff-white solid
      Hill FormulaC₂₀H₂₆O₅
      Chemical formulaC₂₀H₂₆O₅
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      573106 0

      Documentation

      STAT3 Inhibitor X, HJB - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      STAT3 Inhibitor X, HJB - Calbiochem Certificados de análisis

      CargoNúmero de lote
      573106

      Referencias bibliográficas

      Visión general referencias
      Wang, Y., et al. 2009, Canc. Res. 69, 7302.

      Licencias necesarias e Información técnica

      Cargo
      JAK/STAT Signaling Research Focus
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision24-September-2010 JSW
      Synonyms17-Hydroxy-jolkinolide B, HJB
      DescriptionA diterpene diepoxide compound, which demonstrates high selectivity for the JAK/STAT3 signaling pathway and shows anti-tumor properties in certain human cancer cell lines at a concentration of ~12 µM. HJB suppresses IL-6-induced STAT-3 transcription activity (IC50= ˜ 3.34 µM) in HepG2 cells and inhibits IL-6-induced and constitutive STAT-3 tyrosine phosphorylation at a concentration of 10 µM in a select few human cancer cell lines. In HEK 293 culture, HJB hinders JAK kinase activity (IC50 <10 µM) and induces JAK dimerization via cross-linking at a concentration of 20 µM.
      FormOff-white solid
      Chemical formulaC₂₀H₂₆O₅
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWang, Y., et al. 2009, Canc. Res. 69, 7302.