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573099 STAT3 Inhibitor V, Stattic - CAS 19983-44-9 - Calbiochem

STAT3 Inhibitor V, Stattic, CAS 19983-44-9, is a cell-permeable inhibitor of STAT3 cellular function that targets the STAT3-SH2 domain and prevents its association with upstream Kinases.

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Sinónimos: 6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound

Primary Target: STAT3
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573099
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Descripción

Tabla espec. clave

CAS #Empirical Formula
19983-44-9C₈H₅NO₄S

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573099-25MG
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      Description
      OverviewA cell-permeable vinyl-sulfone compound that acts as an inhibitor of STAT3 cellular function by targeting the STAT3-SH2 domain and preventing its association with upstream kinases. The effect of Stattic towards STAT family members is temperature-dependent and appears to be highly STAT3-selective at 37°C. Shown to inhibit cellular phosphorylation of STAT3 at Tyr705 with little effect towards STAT1 phosphorylation at Tyr701 (in HepG2 cells) or the phosphorylation of JAK1, JAK2, and c-Src (in MDA-MB-231 and MDA-MB-235S cells).
      Catalogue Number573099
      Brand Family Calbiochem®
      Synonyms6-Nitrobenzo[b]thiophene-1,1-dioxide, Stat three inhibitory compound
      References
      ReferencesSchust, J., et al. 2006. Chem. Biol. 13, 1235.
      Product Information
      CAS number19983-44-9
      ATP CompetitiveN
      FormPale yellow solid
      Hill FormulaC₈H₅NO₄S
      Chemical formulaC₈H₅NO₄S
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Biological Information
      Primary TargetSTAT3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Irritant
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C. Note: The use of freshly opened DMSO strongly recommended; the thiol impurities present in DMSO will modify the molecule. Highly recommended to reconstitute just before each use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Global Trade Item Number
      Número de referencia GTIN
      573099-25MG 07790788051754