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567790 ST638

A cell-permeable, reversible, and substrate competitive protein tyrosine kinase inhibitor (IC₅₀ = 370 nM) that also inhibits HGF-induced MAP kinase activation in hepatocytes.

ST638: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: α-Cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide

Primary Target: protein tyrosine kinase
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      107761-24-0C₁₉H₁₈N₂O₃S
      Description
      Overview

      This product has been discontinued.





      A cell-permeable, reversible, and substrate competitive protein tyrosine kinase inhibitor (IC50 = 370 nM) that also inhibits HGF-induced MAP kinase activation in hepatocytes. Also shown to inhibit phospholipase D activity in human neutrophils. Decreases the O2· production induced by pervanadate in guinea pig neutrophils.
      Catalogue Number567790
      Brand Family Calbiochem®
      Synonymsα-Cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide
      References
      ReferencesAdachi, T., et al. 1996. Hepatology 23, 1244.
      Yamaguchi, M., et al. 1995. Arch. Biochem. Biophys. 323, 382.
      Uings, I., et al. 1992. Biochem. J. 281, 597.
      Shiraishi, T., et al. 1988. Chem. Pharm. Bull. 36, 974.
      Product Information
      CAS number107761-24-0
      ATP CompetitiveY
      FormPale yellow solid
      Hill FormulaC₁₉H₁₈N₂O₃S
      Chemical formulaC₁₉H₁₈N₂O₃S
      ReversibleY
      Structure formula ImageStructure formula Image
      Applications
      Biological Information
      Primary Targetprotein tyrosine kinase
      Primary Target IC<sub>50</sub>370 nM against protein tyrosine kinase
      Purity≥98% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSUC6316200
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      567790 0

      Documentation

      ST638 Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      ST638 Certificados de análisis

      CargoNúmero de lote
      567790

      Referencias bibliográficas

      Visión general referencias
      Adachi, T., et al. 1996. Hepatology 23, 1244.
      Yamaguchi, M., et al. 1995. Arch. Biochem. Biophys. 323, 382.
      Uings, I., et al. 1992. Biochem. J. 281, 597.
      Shiraishi, T., et al. 1988. Chem. Pharm. Bull. 36, 974.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision04-May-2011 RFH
      Synonymsα-Cyano-(3-ethoxy-4-hydroxy-5-phenylthiomethyl)cinnamide
      DescriptionA cell-permeable, reversible, and substrate competitive protein tyrosine kinase inhibitor (IC50 = 370 nM) that also inhibits HGF-induced MAP kinase activation in hepatocytes. Also shown to inhibit phospholipase D activity in human neutrophils. Decreases the O2· production induced by pervanadate in guinea pig neutrophils.
      FormPale yellow solid
      CAS number107761-24-0
      RTECSUC6316200
      Chemical formulaC₁₉H₁₈N₂O₃S
      Structure formulaStructure formula
      Purity≥98% by HPLC
      SolubilityDMF or DMSO (100 mg/ml)
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
      Toxicity Standard Handling
      ReferencesAdachi, T., et al. 1996. Hepatology 23, 1244.
      Yamaguchi, M., et al. 1995. Arch. Biochem. Biophys. 323, 382.
      Uings, I., et al. 1992. Biochem. J. 281, 597.
      Shiraishi, T., et al. 1988. Chem. Pharm. Bull. 36, 974.