Millipore Sigma Vibrant Logo

573121 SMER28 - CAS 307538-42-7 - Calbiochem

A cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo.

SMER28 - CAS 307538-42-7 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: (6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II

View Products on Sigmaaldrich.com
573121
Ver precios y disponibilidad

Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
307538-42-7C₁₁H₁₀BrN₃

Precios y disponibilidad

Número de referencia DisponiblidadEmbalaje Cant./Env. Precio Cantidad
573121-10MG
Comprobando disponibilidad...
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

      		 Ampolla de plást. 10 mg
      Recuperando precio...
      No pudo obtenerse el precio
      La cantidad mínima tiene que ser múltiplo de
      Maximum Quantity is
      Al finalizar el pedido Más información
      Ahorró ()
       
      —
      Solicitar precio
      		 —
      Description
      OverviewA cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.
      Catalogue Number573121
      Brand Family Calbiochem®
      Synonyms(6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II
      References
      ReferencesTian, Y., et al. 2011. FASEB J. 25, 1934. Sarkar, S., et al. 2007. Nat. Chem. Biol. 3, 331.
      Product Information
      CAS number307538-42-7
      FormPale yellow solid
      Hill FormulaC₁₁H₁₀BrN₃
      Chemical formulaC₁₁H₁₀BrN₃
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Purity≥95% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      573121-10MG 04055977266054

      Documentation

      SMER28 - CAS 307538-42-7 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      SMER28 - CAS 307538-42-7 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      573121

      Referencias bibliográficas

      Visión general referencias
      Tian, Y., et al. 2011. FASEB J. 25, 1934. Sarkar, S., et al. 2007. Nat. Chem. Biol. 3, 331.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-April-2011 RFH
      Synonyms(6-Bromo-4-allylamino)quinazoline, Small-Molecule Enhancer of Rapamycin-28, Autophagy Inducer II
      DescriptionA cell-permeable quinazoline compound that augments the cytostatic effects of Rapamycin (Cat. Nos. 553210 and 553211) in Saccharomyces cerevisiae and acts as an autophagy stimulator both in mammalian cultures in vitro and in a Drosophila melanogaster HD model in vivo. Although SMER28 and Rapamycin do exhibit additive effects on the clearance of cellular autophagy substrates, SMER28 functions independently of Rapamycin by presumably acting on celluar target(s) downstream of the Rapamycin/FKBP12 target, mTOR.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number307538-42-7
      Chemical formulaC₁₁H₁₀BrN₃
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml) or Ethanol (10 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
      Toxicity Standard Handling
      ReferencesTian, Y., et al. 2011. FASEB J. 25, 1934. Sarkar, S., et al. 2007. Nat. Chem. Biol. 3, 331.