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537011 Prolyl Endopeptidase Inhibitor II - CAS 108708-25-4 - Calbiochem

The Prolyl Endopeptidase Inhibitor II, also referenced under CAS 108708-25-4, controls the biological activity of Prolyl Endopeptidase. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Z-PP-CHO

Primary Target: Mouse brain prolylendooeotidase
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      108708-25-4C₁₈H₂₂N₂O₄
      Description
      OverviewA cell-permeable dipeptide aldehyde that acts as a specific, potent, slow, and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain, respectively). Reported to form a hemiacetal with the active site serine of the enzyme.
      Catalogue Number537011
      Brand Family Calbiochem®
      SynonymsZ-PP-CHO
      References
      ReferencesFülöp, V., et al. 1998. Cell 94, 161.
      Kahyaoglu, A., et al. 1997. Biochem. J. 322, 839.
      Bakker, A.V., et al. 1990. Biochem. J. 271, 559.
      Wilk, S., and Orlowski, M. 1983. J. Neurochem. 41, 69.
      Product Information
      CAS number108708-25-4
      ATP CompetitiveN
      FormColorless to off-white oil
      Hill FormulaC₁₈H₂₂N₂O₄
      Chemical formulaC₁₈H₂₂N₂O₄
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetMouse brain prolylendooeotidase
      Primary Target K<sub>i</sub>350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively
      Purity≥97% by HPLC
      Physicochemical Information
      Cell permeableY
      Peptide SequenceZ-Pro-Pro-CHO
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      537011 0

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Prolyl Endopeptidase Inhibitor II - CAS 108708-25-4 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Prolyl Endopeptidase Inhibitor II - CAS 108708-25-4 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      537011

      Referencias bibliográficas

      Visión general referencias
      Fülöp, V., et al. 1998. Cell 94, 161.
      Kahyaoglu, A., et al. 1997. Biochem. J. 322, 839.
      Bakker, A.V., et al. 1990. Biochem. J. 271, 559.
      Wilk, S., and Orlowski, M. 1983. J. Neurochem. 41, 69.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision11-November-2011 JSW
      SynonymsZ-PP-CHO
      DescriptionA cell-permeable dipeptide aldehyde that acts as a specific, potent, slow and tight-binding transition state analog inhibitor of prolyl endopeptidase (Ki = 350 pM and 500 pM for mouse brain and human brain prolyl endopeptidase, respectively). Reported to form a hemiacetal with the active-site serine.
      FormColorless to off-white oil
      Intert gas (Yes/No) Packaged under inert gas
      CAS number108708-25-4
      Chemical formulaC₁₈H₂₂N₂O₄
      Peptide SequenceZ-Pro-Pro-CHO
      Structure formulaStructure formula
      Purity≥97% by HPLC
      SolubilityDMSO (10 mg/ml), DMF, ethyl acetate
      Storage Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesFülöp, V., et al. 1998. Cell 94, 161.
      Kahyaoglu, A., et al. 1997. Biochem. J. 322, 839.
      Bakker, A.V., et al. 1990. Biochem. J. 271, 559.
      Wilk, S., and Orlowski, M. 1983. J. Neurochem. 41, 69.