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506134 Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem

A cell-permeable and very stable analog of Pifithrin-α with similar biological function, but with reduced cytotoxicity.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ

Primary Target: PS3
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      60477-34-1C₁₆H₁₆N₂S · HBr
      Description
      Overview

      This product has been discontinued.



      A cell-permeable and very stable analog of Pifithrin-α (Cat. No. 506132), with similar biological function, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes; also reversibly blocks p53-mediated apoptosis. Acts as a P-gp modulator by changing relative substrate specificity of the transporter. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
      Catalogue Number506134
      Brand Family Calbiochem®
      Synonyms2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ
      References
      ReferencesWalton, M.I., et al. 2005. Mol. Cancer Ther. 4, 1369.
      Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14078.
      Product Information
      CAS number60477-34-1
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₆H₁₆N₂S · HBr
      Chemical formulaC₁₆H₁₆N₂S · HBr
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPS3
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Protect from Moisture Protect from moisture
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      506134 0

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Pifithrin-α, Cyclic- - CAS 60477-34-1 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      506134

      Referencias bibliográficas

      Visión general referencias
      Walton, M.I., et al. 2005. Mol. Cancer Ther. 4, 1369.
      Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14078.

      Folleto

      Cargo
      Caspases and other Apoptosis Related Tools Brochure
      p53 And Related Products
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-April-2008 RFH
      Synonyms2-(4-Methylphenyl)imidazo[2,1-b]-5,6,7,8-tetrahydrobenzothiazole, HBr, QB102, Pifithrin-β, PFTβ
      DescriptionA very stable analog of Pifithrin-α (Cat. No. 506132), with biological properties similar to its parent compound, but with reduced cytotoxicity. A chemical inhibitor of p53. Reversibly inhibits p53-dependent transactivation of p53-responsive genes and reversibly blocks p53-mediated apoptosis. This compound has been reported to be a potent STAT6 transcriptional inhibitor.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number60477-34-1
      Chemical formulaC₁₆H₁₆N₂S · HBr
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (100 mg/ml)
      Storage Protect from moisture
      Protect from light
      -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesWalton, M.I., et al. 2005. Mol. Cancer Ther. 4, 1369.
      Kondratov, R.V., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 14078.