Pellicon® Single-Pass TFF Cassette Accessories

Pellicon^® single-pass tangential flow filtration (single-pass TFF) is a versatile ultrafiltration technology for more productive, high capacity and cost effective downstream processes that allows facilities to meet the demands of high titer and connected or continuous processes.

To run single-pass TFF, Pellicon^® cassettes are installed in existing Pellicon® holders and the serial flow path is generated by use of specially designed diverter plates. The Pellicon^® single-pass TFF mini kit is ideally suited for small-scale applications with mini cassettes. Larger diverter plates are available for process scale-up.

Single-pass TFF is ideal for:

• Achieving high concentrations and high yields
  
• In-process volume concentration for improved facility fit
  
• Intensified performance of chromatography and filtrations steps
  
• Connected and continuous processes

Pellicon^® Cassettes

Integration of single-pass TFF into a biomanufacturing process is easy with Pellicon^® single-pass TFF accessories and existing, proven Pellicon^® cassettes. Our high performance Pellicon^® cassettes deliver high protein yield and consistent product purity and quality, from run to run at every scale and for a variety of drug products.

Benefits

• Easy installation and assembly operation
  
• Use with existing Pellicon® holders and cassettes
  
• Supports scale-down and scale-up applications
  
• Enables intensified, connected and continuous processes

Applications

• Monoclonal antibodies
  
• Recombinant and non-recombinant proteins
  
• Plasma
  
• Vaccines