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540200 PTP Inhibitor I - CAS 2491-38-5 - Calbiochem

PTP Inhibitor I - CAS 2491-38-5 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Protein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II

Primary Target: SHP-1
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      2491-38-5C₈H₇BrO₂
      Description
      Overview

      This product has been discontinued.



      A potent, cell-permeable, and covalent protein tyrosine phosphatase (PTP) inhibitor. Inhibits SHP-1 (ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1 (Ki = 43 µM), and PTPIB (Ki = 42 µM). The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm.
      Catalogue Number540200
      Brand Family Calbiochem®
      SynonymsProtein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II
      References
      ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.
      Product Information
      CAS number2491-38-5
      ATP CompetitiveN
      FormWhite powder
      Hill FormulaC₈H₇BrO₂
      Chemical formulaC₈H₇BrO₂
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetSHP-1
      Primary Target IC<sub>50</sub>43 µM
      Primary Target K<sub>i</sub>43 µM and 42 µM against SHP-1 and PTPIB, respectively
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      R PhraseR: 34-36/37

      Causes burns.
      Irritating to eyes and respiratory system.
      S PhraseS: 26-27-28-36/37/39

      In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
      Take off immediately all contaminated clothing.

      Wear suitable protective clothing, gloves and eye/face protection.
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Blue Ice Only
      Toxicity Corrosive
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage ≤ -70°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsUnstable in DMSO; reconstitute just prior to use.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      540200 0

      Documentation

      PTP Inhibitor I - CAS 2491-38-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      PTP Inhibitor I - CAS 2491-38-5 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      540200

      Referencias bibliográficas

      Visión general referencias
      Arabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.

      Folleto

      Cargo
      Protein Phosphatases Technical Bulletin
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision29-May-2009 JSW
      SynonymsProtein Tyrosine Phosphatase Inhibitor I, α-Bromo-4-hydroxyacetophenone, 4-Hydroxyphenacyl Br, SHP1 Inhibitor II
      DescriptionA potent, cell-permeable, and covalent Protein Tyrosine Phosphatase (PTP) inhibitor. Inhibits SHP-1(ΔSH2), the catalytic domain of the SH2 domain-containing phosphatase SHP-1 (Ki = 43 µM) and PTP1B (Ki = 42 µM), The inhibition can be reversed by irradiation of the inactivated PTP at 350 nm. Unstable in solution.
      FormWhite powder
      Intert gas (Yes/No) Packaged under inert gas
      CAS number2491-38-5
      Chemical formulaC₈H₇BrO₂
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (200 mg/ml)
      Storage Protect from light
      ≤ -70°C
      Do Not Freeze Ok to freeze
      Special InstructionsUnstable in DMSO; reconstitute just prior to use.
      Toxicity Corrosive
      ReferencesArabaci, G., et al. 1999. J. Am. Chem. Soc. 121, 5085.