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505892 PKR Inhibitor III, 7DG CAS 26927-01-5 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: Double-stranded RNA-dependent Protein Kinase Inhibitor III, Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin

Primary Target: PKR
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      26927-01-5C₂₆H₃₀O₅
      Description
      OverviewA cell-permeable gedunin analog that directly targets PKR via reversible interaction inhibits PKR-mediated cellular events by disrupting PKR signaling complexes assembly, such as IκK complex and inflammasome/pyroptosome, resulting in effective blockage of LPS-induced IκBβ degradaion (20 µM) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (10 µM) in murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16 (Cat. Nos. 527450 & 527451), but not by 7DG, while LT-induced pyroptosis in J774 cultures is insensitive to C16 treatment.
      Catalogue Number505892
      Brand Family Calbiochem®
      SynonymsDouble-stranded RNA-dependent Protein Kinase Inhibitor III, Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin
      References
      ReferencesHett, E.C., et al. 2013. Nat. Chem. Biol. 9, 398.
      Product Information
      CAS number26927-01-5
      FormPale yellow solid
      Hill FormulaC₂₆H₃₀O₅
      Chemical formulaC₂₆H₃₀O₅
      ReversibleY
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPKR
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      505892 0

      Documentation

      PKR Inhibitor III, 7DG CAS 26927-01-5 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Referencias bibliográficas

      Visión general referencias
      Hett, E.C., et al. 2013. Nat. Chem. Biol. 9, 398.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision27-September-2013 JSW
      SynonymsDouble-stranded RNA-dependent Protein Kinase Inhibitor III, Double-stranded RNA-activated Protein Kinase Inhibitor III, EIF2AK2 Inhibitor III, 7-Desacetoxy-6,7-dehydrogedunin
      DescriptionA cell-permeable gedunin analog that directly targets PKR via reversible interaction without competing against ATP binding and inhibits PKR-mediated cellular events by disrupting PKR signaling complex assembly, such as IκK complex and inflammasome/pyroptosome, resulting in effective blockage of LPS-induced IκBβ degradaion (20 µM 7DG added 2 h prior to 10 ng/mL LPS) and protection against anthrax toxin LT-induced caspase-1 activation as well as subsequent pyroptosis (by 50% and 100%, respectively, at 5 and 10 µM; 2 h 7DG pretreatment prior to 6 h LT incubation) in J774A.1 BALB/c-derived murine macrophage J774 cultures. PKR is also known to mediate LT-induced apoptosis via its kinase activity in LPS-primed Macrophages derived from C57BL/6 with a resistent NLRP1 allele, inhibitable by C16 (Cat. Nos. 527450 & 527451), but not by 7DG, while LT-induced pyroptosis in J774 cultures is inhibited by 7DG, but insensitive to C16 treatment.
      FormPale yellow solid
      Intert gas (Yes/No) Packaged under inert gas
      CAS number26927-01-5
      Chemical formulaC₂₆H₃₀O₅
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityDMSO (25 mg/ml)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-70°C). Stock solutions are stable for up to 6 months at -70°C.
      Toxicity Standard Handling
      ReferencesHett, E.C., et al. 2013. Nat. Chem. Biol. 9, 398.