Millipore Sigma Vibrant Logo

14-791 PI 3-Kinase (p110α(E542K)/p85α) murine, 10 µg

Complex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K & untagged, recombinant, murine p85α full length.

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
14-791
10 µg  Also available in 250μg size --call for pricing and availability and reference catalog number 14-791M when ordering the 250μg size.
Recuperando precio...
No pudo obtenerse el precio
La cantidad mínima tiene que ser múltiplo de
Maximum Quantity is
Al finalizar el pedido Más información
Ahorró ()
 
—
Solicitar precio
—
Disponibilidad a confirmar Disponibilidad a confirmar
Ingrese cantidad 
Suspendido
Cantidades limitadas disponibles
Debe confirmarse disponibilidad
    El resto: se avisará
      El resto: se avisará
      Se avisará
      Póngase en contacto con el Servicio de Atención al Cliente
      Contact Customer Service

       

      Póngase en contacto con el Servicio de Atención al Cliente

      Descripción

      Replacement Information
      Description
      Catalogue Number14-791
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionPI 3-Kinase (p110α(E542K)/p85α) murine, 10 µg
      OverviewComplex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K, and untagged, recombinant, murine p85α full length.
      Background InformationThe E542K substitution is a somatic mutation in p110α that has been associated with tumours of the colon and brain. Combined in vitro and in vivo studies have shown that this mutation confers higher lipid kinase activity than wild type, and is able to induce oncogenic transformation. (Kang S. et al., PNAS, (2005);102: 802-807 and Zhao J.J. et al., PNAS, (2005);102:18443-18448).
      References
      Product Information
      Presentation50 mM Tris/HCl pH7.5, 300 mM NaCl, 0.1 mM EGTA, 0.03% Brij-35, 270 mM sucrose, 0.2 mM PMSF, 1 mM benzamidine, 0.1% 2-mercaptoethanol. Frozen solution.
      Quality LevelMQ300
      Applications
      ApplicationComplex of N-terminal 6His-tagged recombinant murine p110α full length, containing the mutation E542K & untagged, recombinant, murine p85α full length.
      Biological Information
      SourceCo-expressed by baculovirus in Sf21 insect cells.
      Specific ActivityFor Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.
      Entrez Gene Number
      Gene Symbol
      • PIK3CA
      • PI3K
      • PK3CA
      Protein TargetPI3Kα/p85α
      Purification MethodNi2+/NTA-agarose
      Target Sub-FamilyPI3K/PI4K
      UniProt Number
      Molecular Weightp110α(E542K) MW = 129 kDa, p85α MW = 84 kDa.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStore at -70°C from date of shipment. For maximum recovery of product, centrifuge original vial prior to removing the cap.
      Packaging Information
      Material Size10 µg
      Material PackageAlso available in 250μg size --call for pricing and availability and reference catalog number 14-791M when ordering the 250μg size.
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-791 04053252679087

      Productos y aplicaciones relacionados

      Alternative Packsize

      Número de referencia Descripción  
      14-791M PI 3-Kinase (p110α(E542K)/p85α) murine, 250 µg Precios y disponibilidad

      Accessories

      Número de referencia Descripción  
      14-558 PI3 Kinase (p120γ), 20 µg Precios y disponibilidad
      14-602 PI3 Kinase (p110α/p85α) Protein, active, 20 µg Precios y disponibilidad
      14-603 PI3 Kinase (p110β/p85α) Protein, active, 20 µg Precios y disponibilidad
      14-604 PI3 Kinase (p110δ/p85α) Protein, active, 10 µg Precios y disponibilidad
      14-781 PI3 Kinase (p110α(E545K)/p85α), Murine, 10 µg Precios y disponibilidad
      14-782 PI 3-Kinase (p110α(E542K)/p85α), Human, 10 µg Precios y disponibilidad
      14-783 PI3 Kinase (p110α(E545K)/p85α), 10 µg Precios y disponibilidad
      14-785 PI3 Kinase (p110α/p85α) murine, 10 µg Precios y disponibilidad
      14-786 PI3 Kinase (p110α/p65α) Murine, 10 µg Precios y disponibilidad
      14-787 PI3 Kinase (p110α (H1047R)/p85α) Murine, 10 µg Precios y disponibilidad
      Show more

      Familias de productos

      Kinase & Phosphatase Products

      Millipore offers a large portfolio of Kinases, Phophatases, Substrates, Inhibitors, Kits, reagents & tools for Signaling research. See below for a list of these products, in multiple pack sizes.
      Más información >>

      Categorías

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases