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324473 PARP Inhibitor IX, EB-47 - Calbiochem

The PARP Inhibitor IX, EB-47 controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

PARP Inhibitor IX, EB-47 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.
Primary Target: PARP-1
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324473
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Descripción

Replacement Information

Tabla espec. clave

Empirical Formula
C₂₄H₂₇N₉O₆·2HCl·2H₂O

Precios y disponibilidad

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324473-1MG
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      Description
      OverviewA cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of PARP-1 (IC50 = 45 nM). Shown to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
      Catalogue Number324473
      Brand Family Calbiochem®
      References
      ReferencesJagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.
      Product Information
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
      Chemical formulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
      Hygroscopic Hygroscopic
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPARP-1
      Primary Target IC<sub>50</sub>45 nM
      Purity≥95% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped with Blue Ice or with Dry Ice
      Toxicity Carcinogenic / Teratogenic
      Storage -20°C
      Protect from Light Protect from light
      Hygroscopic Hygroscopic
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      324473-1MG 04055977197235

      Documentation

      Licencias necesarias

      Título
      PRODUCTO REGULADO POR LA SECRETARÍA DE SALUD

      PARP Inhibitor IX, EB-47 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      PARP Inhibitor IX, EB-47 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      324473

      Referencias bibliográficas

      Visión general referencias
      Jagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision19-June-2008 RFH
      DescriptionA cell-permeable, adenosine-substituted, isoindolinone compound that acts as a potent inhibitor of poly (ADP-ribose) polymerase-1 (PARP-1) (IC50 = 45 nM). Reported to offer cytoprotective effects against oxidative damage in cells and in in vivo models of reperfusion injury and inflammation.
      FormWhite solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₂₄H₂₇N₉O₆·2HCl·2H₂O
      Structure formulaStructure formula
      Purity≥95% by HPLC
      SolubilityH₂O (50 mg/ml)
      Storage Protect from light
      -20°C
      Hygroscopic
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Carcinogenic / Teratogenic
      ReferencesJagtap, P.G., et al. 2004. Bioorg. Med. Chem. Lett. 14, 81.