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475840 Milrinone - CAS 78415-72-2 - Calbiochem

A cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC₅₀ = 300 nM).

Milrinone - CAS 78415-72-2 - Calbiochem: Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile

Primary Target: PDE 3
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      Descripción

      Replacement Information

      Tabla espec. clave

      CAS #Empirical Formula
      78415-72-2C₁₂H₉N₃O
      Description
      OverviewA cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III; IC50 = 300 nM). Has positive chronotropic, inotropic, and vasodilatory effects on the heart.
      Catalogue Number475840
      Brand Family Calbiochem®
      Synonyms1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
      References
      ReferencesBailey, J.M., et al. 1994. Anesthesiology 81, 616.
      Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
      Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
      Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.
      Product Information
      CAS number78415-72-2
      ATP CompetitiveN
      FormWhite solid
      Hill FormulaC₁₂H₉N₃O
      Chemical formulaC₁₂H₉N₃O
      ReversibleN
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetPDE 3
      Primary Target IC<sub>50</sub>300 nM against PDE III
      Purity≥99% by HPLC
      Physicochemical Information
      Cell permeableY
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      RTECSDW1762000
      Safety Information
      R PhraseR: 23/24/25

      Toxic by inhalation, in contact with skin and if swallowed.
      S PhraseS: 36/37/39-45

      Wear suitable protective clothing, gloves and eye/face protection.
      In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Toxic
      Hazardous Materials Attention: Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      475840 0

      Documentation

      Milrinone - CAS 78415-72-2 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Milrinone - CAS 78415-72-2 - Calbiochem Certificados de análisis

      CargoNúmero de lote
      475840

      Referencias bibliográficas

      Visión general referencias
      Bailey, J.M., et al. 1994. Anesthesiology 81, 616.
      Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
      Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
      Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision17-July-2014 JSW
      Synonyms1,6-Dihydro-2-methyl-6-oxo-(3,4ʹ-bipyridine)-5-carbonitrile
      DescriptionA cell-permeable, selective inhibitor of cGMP-inhibited phosphodiesterase (PDE III, IC50 = 300 nM). Has positive chronotropic, ionotropic, and vasodilatory effects on the heart.
      FormWhite solid
      CAS number78415-72-2
      RTECSDW1762000
      Chemical formulaC₁₂H₉N₃O
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityDMSO (20 mg/ml) or Ethanol (3 mg/ml)
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 2 months at -20°C.
      Toxicity Toxic
      Merck USA index14, 6197
      ReferencesBailey, J.M., et al. 1994. Anesthesiology 81, 616.
      Wilhelm, D., et al. 1992. J. Cardiovasc. Pharmacol. 20, 705.
      Lindgren, S.H., et al. 1990. Acta. Phys. Scand. 140, 209.
      Harrison, S.A., et al. 1986. Mol. Pharmacol. 29, 506.