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504633 MTEP Hydrochloride - CAS 1186195-60-7 - Calbiochem

Ficha de datos de seguridad (MSDS o SDS), certificado de análisis y de calidad (CoA y CoQ), expedientes, folletos y otros documentos disponibles.

Sinónimos: 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride

Primary Target: mGlu₅ receptors
504633
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Descripción

Replacement Information

Tabla espec. clave

CAS #Empirical Formula
1186195-60-7C₁₁H₈N₂SHCl

Precios y disponibilidad

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      Description
      OverviewA non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5 nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
      Catalogue Number504633
      Brand Family Calbiochem®
      Synonyms3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride
      References
      ReferencesCosford, N., et al. 2003. J. Med. Chem. 46, 204.
      Varty, B., et al. 2005. Psychopharmacol. 179, 207.
      Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
      Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
      McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
      Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
      Wang, X., et al. 2013. Addict. Biol. 18, 40.
      Product Information
      CAS number1186195-60-7
      FormCream solid
      Hill FormulaC₁₁H₈N₂SHCl
      Chemical formulaC₁₁H₈N₂SHCl
      Structure formula ImageStructure formula Image
      Quality LevelMQ100
      Applications
      Biological Information
      Primary TargetmGlu₅ receptors
      Primary Target IC<sub>50</sub>5 nM
      Purity≥99% by HPLC
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
      Toxicity Standard Handling
      Storage +2°C to +8°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      5.04633.0001 04055977243963

      Documentation

      MTEP Hydrochloride - CAS 1186195-60-7 - Calbiochem Ficha datos de seguridad (MSDS)

      Título

      Ficha técnica de seguridad del material (MSDS) 

      Referencias bibliográficas

      Visión general referencias
      Cosford, N., et al. 2003. J. Med. Chem. 46, 204.
      Varty, B., et al. 2005. Psychopharmacol. 179, 207.
      Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
      Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
      McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
      Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
      Wang, X., et al. 2013. Addict. Biol. 18, 40.
      Ficha técnica

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision12-July-2013 JSW
      Synonyms3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine hydrochloride
      DescriptionA non-competitive, potent antagonist highly selective for mGlu5 receptors (IC50 = 5 nM). Biologically active admitted orally or systematically. Widely used in assessing the functional roles of mGlu5 receptors in a variety of research areas, such as neuroprotection, depression, addiction, anxiety and stress related disorders, analgesia, locomotion, neural plasticity, and Parkinson's disease.
      FormCream solid
      CAS number1186195-60-7
      Chemical formulaC₁₁H₈N₂SHCl
      Structure formulaStructure formula
      Purity≥99% by HPLC
      SolubilityH₂O (100 mM)
      Storage Protect from light
      +2°C to +8°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesCosford, N., et al. 2003. J. Med. Chem. 46, 204.
      Varty, B., et al. 2005. Psychopharmacol. 179, 207.
      Domin, H., et al. 2006. Pharmacol. Reports. 58, 846.
      Johnston, Tom H., et al. 2010. J. Pharmacol. & Exp. Therapeutics 333, 865.
      McIldowie, M., et al. 2010. J. Pharm. Sci. 99, 234.
      Timmer, M., et al. 2012. Psychopharmacol. 221, 91.
      Wang, X., et al. 2013. Addict. Biol. 18, 40.