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14-695M MST3 Protein, active, 250 µg

Active, N-terminal GST-tagged, recombinant, human MST3, amino acids 1-304, for use in Kinase Assays.

14-695M
250 µg  Also available in 10 μg size (cat#14-695) and in bulk (cat#14-695-K).
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      Descripción

      Replacement Information
      Description
      Catalogue Number14-695M
      Brand Family Upstate
      Trade Name
      • Upstate
      DescriptionMST3 Protein, active, 250 µg
      OverviewN-terminal GST-tagged, recombinant, human MST3, amino acids 1-304
      References
      Product Information
      Quality LevelMQ300
      Applications
      ApplicationActive, N-terminal GST-tagged, recombinant, human MST3, amino acids 1-304, for use in Kinase Assays.
      Key Applications
      • Kinase Assay
      Biological Information
      Sourceexpressed by baculovirus in Sf21 cells
      Entrez Gene Number
      Entrez Gene SummaryThe yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM]
      Gene Symbol
      • STK24
      • MST3B
      • MST3
      • MST-3
      • STK3
      Protein TargetMST3
      Purification MethodGlutathione agarose affinity chromatography
      Target Sub-FamilySTE
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9Y6E0 # Protein kinase that act on both serine and threonine residues.
      COFACTOR: Manganese. Only isoform A requires manganese.
      SIZE: 443 amino acids; 49308 Da
      SUBCELLULAR LOCATION: Cytoplasm (By similarity).
      TISSUE SPECIFICITY: Isoform A is ubiquitous. Isoform B is expressed in brain with high expression in hippocampus and cerebral cortex.
      PTM: Autophosphorylated. Isoform B is activated by phosphorylation by PKA.
      SIMILARITY: SwissProt: Q9Y6E0 ## Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. & Contains 1 protein kinase domain.
      Molecular Weight61.2kDa
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceRoutinely evaluated by phosphorylation of PKCtide (Catalog# 12-536)
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage Conditionsstable for 6 months at -70°C from date of shipment
      Packaging Information
      Material Size250 µg
      Material PackageAlso available in 10 μg size (cat#14-695) and in bulk (cat#14-695-K).
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Número de referencia GTIN
      14-695M 04053252925368

      Documentation

      Productos y aplicaciones relacionados

      Alternative Packsize

      Número de referencia Descripción  
      14-695 MST3 Protein, active, 10 µg Precios y disponibilidad

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      Categorías

      Life Science Research > Proteins and Enzymes > Purified Kinases
      Life Science Research > Drug Discovery and Development > Kinase & Phosphatase Screening > Purified Kinases